D.E. Shaw & Co
MDGL icon

D.E. Shaw & Co’s Madrigal Pharmaceuticals MDGL Stock Holding History

D.E. Shaw & Co’s Portfolio MDGL Stock Details MDGL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$10.5M Hold
19,500
– – 0.01% 1771
2026
Q1 		$10.2M Sell
19,500
-7,800
-29% -$3.73M 0.01% 1621
2025
Q4 		$15.9M Buy
27,300
+2,600
+11% +$1.33M 0.01% 1391
2025
Q3 		$11.3M Buy
24,700
+16,100
+187% +$6.01M 0.01% 1580
2025
Q2 		$2.6M Buy
8,600
+100
+1% +$29.8K ﹤0.01% 2548
2025
Q1 		$2.82M Hold
8,500
– – ﹤0.01% 2347
2024
Q4 		$2.62M Buy
+8,500
New +$2.39M ﹤0.01% 2515
2024
Q3 		– Sell
-900
Closed -$252K – 4747
2024
Q2 		$252K Sell
900
-8,200
-90% -$1.95M ﹤0.01% 3980
2024
Q1 		$2.43M Buy
+9,100
New +$2.14M ﹤0.01% 2479
2021
Q4 		– Sell
-10,000
Closed -$798K – 5575
2021
Q3 		$798K Hold
10,000
– – ﹤0.01% 3777
2021
Q2 		$974K Buy
10,000
+6,200
+163% +$734K ﹤0.01% 3565
2021
Q1 		$444K Buy
+3,800
New +$443K ﹤0.01% 3557
2020
Q1 		– Sell
-10,000
Closed -$911K – 4118
2019
Q4 		$911K Sell
10,000
-10,000
-50% -$970K ﹤0.01% 3056
2019
Q3 		$1.72M Sell
20,000
-10,000
-33% -$938K ﹤0.01% 2468
2019
Q2 		$3.14M Buy
30,000
+9,200
+44% +$985K ﹤0.01% 1930
2019
Q1 		$2.6M Buy
20,800
+10,000
+93% +$1.24M ﹤0.01% 1977
2018
Q4 		$1.22M Buy
+10,800
New +$1.67M ﹤0.01% 2527

Other funds holding MDGL

BBA
Baker Bros. Advisors New York $20B AUM 154.41% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
PC
Paulson & Co New York $2.58B AUM 68.51% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Wellington Management Group
Wellington Management Group Boston, Massachusetts $580B AUM 38.23% 1-Year Est. Return
Vanguard Portfolio Management
Vanguard Portfolio Management Malvern, Pennsylvania $2.22T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

D.E. Shaw & Co's MDGL Position: Q2 2026 in Review

D.E. Shaw & Co increased its Madrigal Pharmaceuticals (MDGL) stake by 16% in Q2 2026, buying an estimated $2.53M and bringing the position to 35,071 shares worth $18.8M. The position accounts for 0.01% of the portfolio, ranked #1322.

D.E. Shaw & Co first reported a position in MDGL in Q2 2013 and has held it in 40 quarters since. The position peaked at $51.6M in Q4 2025. 414 funds tracked by Wall St. Rank hold MDGL as of Q2 2026.

  • D.E. Shaw & Co held 35,071 shares of Madrigal Pharmaceuticals worth $18.8M as of Q2 2026.
  • D.E. Shaw & Co bought 4,932 Madrigal Pharmaceuticals shares in Q2 2026, an estimated $2.53M.
  • Madrigal Pharmaceuticals made up 0.01% of D.E. Shaw & Co's portfolio in Q2 2026, its #1322 holding.
  • D.E. Shaw & Co first reported a position in Madrigal Pharmaceuticals in Q2 2013 and has held it in 40 quarters since.
  • D.E. Shaw & Co's Madrigal Pharmaceuticals position peaked at $51.6M in Q4 2025.
  • 414 funds tracked by Wall St. Rank held Madrigal Pharmaceuticals as of Q2 2026.

Based on D.E. Shaw & Co's 13F filing for Q2 2026, filed 14 Aug 2026.