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Madrigal Pharmaceuticals

387 hedge funds and large institutions have $13.7B invested in Madrigal Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 85 funds opening new positions, 137 increasing their positions, 113 reducing their positions, and 41 closing their positions.

New
Increased
Maintained
Reduced
Closed

107% more first-time investments, than exits

New positions opened: 85 | Existing positions closed: 41

28% more capital invested

Capital invested by funds: $10.7B → $13.7B (+$2.99B)

21% more repeat investments, than reductions

Existing positions increased: 137 | Existing positions reduced: 113

19% more call options, than puts

Call options by funds: $323M | Put options by funds: $271M

10% more funds holding

Funds holding: 352387 (+35)

1.57% less ownership

Funds ownership: 105.34%103.78% (-1.6%)

7% less funds holding in top 10

Funds holding in top 10: 1413 (-1)

Holders
387
Holders Change
+35
Holders Change %
+9.94%
% of All Funds
4.71%
Holding in Top 10
13
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-7.14%
% of All Funds
0.16%
New
85
Increased
137
Reduced
113
Closed
41
Calls
$323M
Puts
$271M
Net Calls
+$52.6M
Net Calls Change
-$16.2M
Name Holding Trade Value Shares
Change
Change in
Stake
BBA
1
Baker Bros. Advisors
New York
$1.25B
RI
2
RTW Investments
New York
$1.16B
Vanguard Group
3
Vanguard Group
Pennsylvania
$1.05B -$1.61M -3,160 -0.2%
ACA
4
Avoro Capital Advisors
New York
$1.05B -$13M -25,500 -1%
PC
5
Paulson & Co
New York
$994M -$102M -200,001 -10%
BlackRock
6
BlackRock
New York
$958M +$43.4M +85,038 +5%
Janus Henderson Group
7
Janus Henderson Group
United Kingdom
$918M -$132M -257,847 -14%
State Street
8
State Street
Massachusetts
$340M -$38.4M -75,094 -11%
Wellington Management Group
9
Wellington Management Group
Massachusetts
$269M +$29.1M +56,947 +14%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$263M +$2.81M +5,510 +1%
Fidelity Investments
11
Fidelity Investments
Massachusetts
$256M +$19.5M +38,262 +10%
Bank of America
12
Bank of America
North Carolina
$242M +$87.7M +171,733 +70%
Invesco
13
Invesco
Georgia
$213M +$33.6M +65,749 +22%
William Blair Investment Management
14
William Blair Investment Management
Illinois
$206M -$29.4M -57,582 -14%
T. Rowe Price Associates
15
T. Rowe Price Associates
Maryland
$183M -$19.8M -38,861 -11%
Goldman Sachs
16
Goldman Sachs
New York
$178M -$41M -80,253 -21%
PCH
17
Polar Capital Holdings
United Kingdom
$157M +$2.55M +4,997 +2%
AC
18
Armistice Capital
New York
$155M +$74.4M +145,723 +121%
HRCM
19
Hood River Capital Management
Florida
$144M +$2.43M +4,752 +2%
Lord, Abbett & Co
20
Lord, Abbett & Co
New Jersey
$143M +$72.9M +142,653 +140%
Alkeon Capital Management
21
Alkeon Capital Management
New York
$140M +$61.3M +120,000 +100%
Charles Schwab
22
Charles Schwab
California
$128M +$2.78M +5,447 +3%
Artisan Partners
23
Artisan Partners
Wisconsin
$116M -$3.86M -7,561 -4%
Norges Bank
24
Norges Bank
Norway
$114M +$100M +196,393 New
Deutsche Bank
25
Deutsche Bank
Germany
$112M +$79M +154,767 +414%