Baker Bros. Advisors’s Prelude Therapeutics PRLD Stock Holding History

Baker Bros. Advisors’s Portfolio PRLD Stock Details PRLD Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$54M	Hold	10,123,824	–	–	0.27%	35
2026 Q1	$34.6M	Hold	10,123,824	–	–	0.2%	42
2025 Q4	$29.4M	Hold	10,123,824	–	–	0.17%	43
2025 Q3	$14.6M	Hold	10,123,824	–	–	0.11%	55
2025 Q2	$8.19M	Hold	10,123,824	–	–	0.08%	56
2025 Q1	$7.78M	Hold	10,123,824	–	–	0.09%	49
2024 Q4	$12.9M	Hold	10,123,824	–	–	0.14%	48
2024 Q3	$21M	Hold	10,123,824	–	–	0.22%	41
2024 Q2	$38.6M	Hold	10,123,824	–	–	0.49%	28
2024 Q1	$48M	Hold	10,123,824	–	–	0.6%	27
2023 Q4	$43.2M	Hold	10,123,824	–	–	0.49%	25
2023 Q3	$31.3M	Hold	10,123,824	–	–	0.18%	25
2023 Q2	$45.6M	Hold	10,123,824	–	–	0.26%	26
2023 Q1	$57.7M	Hold	10,123,824	–	–	0.31%	20
2022 Q4	$61.1M	Hold	10,123,824	–	–	0.37%	21
2022 Q3	$66.9M	Hold	10,123,824	–	–	0.44%	22
2022 Q2	$52.8M	Hold	10,123,824	–	–	0.3%	23
2022 Q1	$69.9M	Hold	10,123,824	–	–	0.4%	22
2021 Q4	$126M	Hold	10,123,824	–	–	0.61%	15
2021 Q3	$316M	Hold	10,123,824	–	–	1.39%	9
2021 Q2	$290M	Hold	10,123,824	–	–	1.27%	10
2021 Q1	$439M	Buy	10,123,824 +5,188	+0.1%	+$344K	1.9%	10
2020 Q4	$724M	Hold	10,118,636	–	–	2.73%	7
2020 Q3	$305M	Buy	+10,118,636	New	+$286M	1.22%	11

Other funds holding PRLD

OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

SCM

Soleus Capital Management Greenwich, Connecticut $2.9B AUM 169.69% 1-Year Est. Return

KCM

Kynam Capital Management Princeton, New Jersey $1.81B AUM 192.15% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

SFM

Sphera Funds Management Tel Aviv, Israel $767M AUM 119.71% 1-Year Est. Return

Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

ACM

ADAR1 Capital Management Austin, Texas $2.19B AUM 374.99% 1-Year Est. Return

Millennium Management New York $276B AUM 44.8% 1-Year Est. Return

Baker Bros. Advisors's PRLD Position: Q2 2026 in Review

Baker Bros. Advisors held its Prelude Therapeutics (PRLD) position steady in Q2 2026 at 10,123,824 shares worth $54M. The position accounts for 0.27% of the portfolio, ranked #35.

Baker Bros. Advisors first reported a position in PRLD in Q3 2020 and has held it in 24 quarters since. The position peaked at $724M in Q4 2020. 75 funds tracked by Wall St. Rank hold PRLD as of Q2 2026.

Baker Bros. Advisors held 10,123,824 shares of Prelude Therapeutics worth $54M as of Q2 2026.
Baker Bros. Advisors left its Prelude Therapeutics share count unchanged in Q2 2026.
Prelude Therapeutics made up 0.27% of Baker Bros. Advisors's portfolio in Q2 2026, its #35 holding.
Baker Bros. Advisors first reported a position in Prelude Therapeutics in Q3 2020 and has held it in 24 quarters since.
Baker Bros. Advisors's Prelude Therapeutics position peaked at $724M in Q4 2020.
75 funds tracked by Wall St. Rank held Prelude Therapeutics as of Q2 2026.

Based on Baker Bros. Advisors's 13F filing for Q2 2026, filed 14 Aug 2026.