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Prelude Therapeutics
PRLD

Overview Fund Activity

58 hedge funds and large institutions have $26.9M invested in Prelude Therapeutics in 2025 Q1 according to their latest regulatory filings, with 4 funds opening new positions, 18 increasing their positions, 24 reducing their positions, and 7 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
58
Holders Change
-4
Holders Change %
-6.45%
% of All Funds
0.79%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
4
Increased
18
Reduced
24
Closed
7
Calls
$18K
Puts
–
Net Calls
+$18K
Net Calls Change
+$10K

Top Buyers

1
BCM
Boxer Capital Management
California
+$308K
2
Acadian Asset Management
Acadian Asset Management
Massachusetts
+$33.6K
3
Northern Trust
Northern Trust
Illinois
+$25.7K
4
UBS Group
UBS Group
Switzerland
+$22.1K
5
Simplex Trading
Simplex Trading
Illinois
+$17.6K

Top Sellers

1
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$850K
2
Massachusetts Financial Services
Massachusetts Financial Services
Massachusetts
-$630K
3
Marshall Wace
Marshall Wace
United Kingdom
-$498K
4
Millennium Management
Millennium Management
New York
-$243K
5
RhumbLine Advisers
RhumbLine Advisers
Massachusetts
-$116K
Name Holding Trade Value Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$8.38M – – –
BBA
2
Baker Bros. Advisors
New York
$7.78M – – –
NL
3
Nuveen LLC
North Carolina
$3.62M +$3.62M +187,613 New
BCM
4
Boxer Capital Management
California
$1.62M +$308K +399,827 +23%
BlackRock
5
BlackRock
New York
$805K -$16.9K -22,048 -2%
Vanguard Group
6
Vanguard Group
Pennsylvania
$775K -$912 -1,188 -0.1%
T. Rowe Price Associates
7
T. Rowe Price Associates
Maryland
$750K -$40.8K -53,052 -5%
Renaissance Technologies
8
Renaissance Technologies
New York
$504K +$17.1K +22,200 +3%
Acadian Asset Management
9
Acadian Asset Management
Massachusetts
$405K +$33.6K +43,946 +9%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$311K +$2.01K +2,619 +0.7%
Morgan Stanley
11
Morgan Stanley
New York
$233K -$47.9K -62,380 -17%
State Street
12
State Street
Massachusetts
$220K -$5.65K -7,350 -3%
Two Sigma Advisers
13
Two Sigma Advisers
New York
$200K -$30.4K -39,600 -13%
Two Sigma Investments
14
Two Sigma Investments
New York
$141K -$37K -48,172 -21%
TD Asset Management
15
TD Asset Management
Ontario, Canada
$123K – – –
Goldman Sachs
16
Goldman Sachs
New York
$119K +$5.29K +6,889 +5%
Millennium Management
17
Millennium Management
New York
$113K -$243K -315,785 -68%
Northern Trust
18
Northern Trust
Illinois
$89.8K +$25.7K +33,520 +40%
Charles Schwab
19
Charles Schwab
California
$87.6K -$2.42K -3,150 -3%
UBS Group
20
UBS Group
Switzerland
$73.8K +$22.1K +28,766 +43%
BCM
21
Bridgeway Capital Management
Texas
$68K -$17.3K -22,500 -20%
Deutsche Bank
22
Deutsche Bank
Germany
$62.2K -$33.2K -43,176 -35%
Susquehanna International Group
23
Susquehanna International Group
Pennsylvania
$59.8K +$3.9K +5,071 +7%
Manulife (Manufacturers Life Insurance)
24
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$53.2K -$609 -793 -1%
Simplex Trading
25
Simplex Trading
Illinois
$32K +$17.6K +23,032 +122%
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