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5VM

5AM Venture Management Portfolio holdings

AUM $360M
1-Year Est. Return 345.76%
This Fund
S&P 500
This Quarter Est. Return
-28.61%
1 Year Est. Return
+345.76%
3 Year Est. Return
+491.51%
5 Year Est. Return
+330.26%
10 Year Est. Return
–
AUM
$264M
AUM Growth
-$155M
Cap. Flow
-$10.4M
Cap. Flow %
-3.92%
Top 10 Hldgs %
63.89%
Holding
32
New
1
Increased
–
Reduced
2
Closed
1

Top Buys

Rank Stock Value
1
SRZN icon
Surrozen
SRZN
+$3.6M

Top Sells

Rank Stock Value
1
ELVN icon
Enliven Therapeutics
ELVN
+$6.61M
2
AKRO
Akero Therapeutics
AKRO
+$4.59M
3
TECX
Tectonic Therapeutic
TECX
+$2.77M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ADVM
26
DELISTED
Adverum Biotechnologies
ADVM
$2.37M 0.9%
541,666
– –
SLN
27
Silence Therapeutics
SLN
$525M
$1.34M 0.51%
476,200
– –
ALEC icon
28
Alector
ALEC
$173M
$1.22M 0.46%
995,841
– –
CDTX
29
DELISTED
Cidara Therapeutics
CDTX
$1.22M 0.46%
56,725
– –
ZNTL icon
30
Zentalis Pharmaceuticals
ZNTL
$345M
$779K 0.29%
490,000
– –
MRSN
31
DELISTED
Mersana Therapeutics
MRSN
$449K 0.17%
52,200
– –
AKRO
32
DELISTED
Akero Therapeutics
AKRO
– –
-165,000
Closed -$4.59M
1
2

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RA
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SWM
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NC
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MCM
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KLWA
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PWC
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5AM Venture Management's Q1 2025 Portfolio in Review

As of Q1 2025, 5AM Venture Management held 32 positions worth $264M, down 37% from $419M the previous quarter. Its ten largest holdings account for 64% of the portfolio.

5AM Venture Management withdrew a net $10.4M in Q1 2025, closing 1 position and reducing 2 holdings. Its most notable exit was Akero Therapeutics, an estimated $4.59M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

Against the trend, 5AM Venture Management opened a new position in Surrozen worth $3.61M.

  • 5AM Venture Management's largest Q1 2025 buy was Surrozen: 310,000 shares worth $3.61M.
  • 5AM Venture Management's biggest Q1 2025 reduction was Enliven Therapeutics, cutting an estimated $6.61M.
  • 5AM Venture Management fully exited Akero Therapeutics in Q1 2025, selling an estimated $4.59M.
  • 5AM Venture Management's ten largest holdings make up 64% of its $264M portfolio in Q1 2025.
  • 5AM Venture Management opened 1 new position and closed 1 in Q1 2025.
  • 5AM Venture Management's portfolio value fell 37% quarter-over-quarter to $264M.

Based on 5AM Venture Management's 13F filing for Q1 2025, filed 15 May 2025.