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Vertex Pharmaceuticals
VRTX

1,519 hedge funds and large institutions have $90.8B invested in Vertex Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 143 funds opening new positions, 550 increasing their positions, 617 reducing their positions, and 156 closing their positions.

New
Increased
Maintained
Reduced
Closed

59% more call options, than puts

Call options by funds: $846M | Put options by funds: $533M

8% less first-time investments, than exits

New positions opened: 143 | Existing positions closed: 156

3% less funds holding

Funds holding: 1,559 → 1,519 (-40)

3.23% less ownership

Funds ownership: 93.81% → 90.59% (-3.2%)

11% less repeat investments, than reductions

Existing positions increased: 550 | Existing positions reduced: 617

15% less capital invested

Capital invested by funds: $107B → $90.8B (-$16.4B)

56% less funds holding in top 10

Funds holding in top 10: 16 → 7 (-9)

Holders
1,519
Holders Change
-40
Holders Change %
-2.57%
% of All Funds
19.94%
Holding in Top 10
7
Holding in Top 10 Change
-9
Holding in Top 10 Change %
-56.25%
% of All Funds
0.09%
New
143
Increased
550
Reduced
617
Closed
156
Calls
$846M
Puts
$533M
Net Calls
+$313M
Net Calls Change
-$63.9M

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$858M
2
ClearBridge Investments
ClearBridge Investments
New York
+$467M
3
JP Morgan Chase
JP Morgan Chase
New York
+$236M
4
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$218M
5
Capital Research Global Investors
Capital Research Global Investors
California
+$186M

Top Sellers

1
Fidelity Investments
Fidelity Investments
Massachusetts
-$1.3B
2
Capital World Investors
Capital World Investors
California
-$1.18B
3
Jennison Associates
Jennison Associates
New York
-$1.13B
4
Edgewood Management
Edgewood Management
Connecticut
-$404M
5
Massachusetts Financial Services
Massachusetts Financial Services
Massachusetts
-$326M
Name Holding Trade Value Shares
Change 		Change in
Stake
Parnassus Investments
26
Parnassus Investments
California
$646M -$26.3M -63,007 -4%
Deutsche Bank
27
Deutsche Bank
Germany
$627M +$80.6M +192,822 +14%
Bank of New York Mellon
28
Bank of New York Mellon
New York
$615M -$13.1M -31,308 -2%
Edgewood Management
29
Edgewood Management
Connecticut
$583M -$404M -967,405 -39%
Goldman Sachs
30
Goldman Sachs
New York
$581M -$187M -447,102 -23%
DZ Bank
31
DZ Bank
Germany
$525M +$56.7M +135,674 +11%
Royal Bank of Canada
32
Royal Bank of Canada
Ontario, Canada
$468M -$79.7M -190,659 -14%
WCM Investment Management
33
WCM Investment Management
California
$455M -$5.66M -13,538 -1%
Amundi
34
Amundi
France
$451M -$5.96M -14,255 -1%
N
35
Nuveen
North Carolina
$422M +$6.47M +15,475 +1%
Pictet Asset Management
36
Pictet Asset Management
Switzerland
$311M +$23.3M +55,636 +8%
Dimensional Fund Advisors
37
Dimensional Fund Advisors
Texas
$307M +$78.3M +187,359 +31%
UBS Group
38
UBS Group
Switzerland
$303M +$30.5M +73,046 +10%
Assenagon Asset Management
39
Assenagon Asset Management
Luxembourg
$299M +$218M +520,949 +215%
Barclays
40
Barclays
United Kingdom
$291M -$33.6M -80,450 -10%
Swiss National Bank
41
Swiss National Bank
Switzerland
$290M -$15.9M -38,000 -5%
Renaissance Technologies
42
Renaissance Technologies
New York
$288M -$112M -269,000 -27%
Wells Fargo
43
Wells Fargo
California
$281M +$6.38M +15,274 +2%
Sumitomo Mitsui Trust Group
44
Sumitomo Mitsui Trust Group
Japan
$274M +$19.1M +45,623 +7%
HSBC Holdings
45
HSBC Holdings
United Kingdom
$249M -$1.93M -4,629 -0.7%
California Public Employees Retirement System
46
California Public Employees Retirement System
California
$240M -$47M -112,548 -16%
Squarepoint
47
Squarepoint
New York
$238M +$181M +432,149 +246%
Mitsubishi UFJ Asset Management
48
Mitsubishi UFJ Asset Management
Japan
$213M +$8.38M +20,053 +4%
Lazard Asset Management
49
Lazard Asset Management
New York
$213M +$27M +64,513 +13%
Citigroup
50
Citigroup
New York
$211M -$24.7M -59,084 -10%
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VRTX Hedge Fund Activity: Q3 2025 in Review

1,519 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Vertex Pharmaceuticals (VRTX) for Q3 2025, worth a combined $90.8B — down 15% from $107B a quarter earlier.

Sellers outnumbered buyers: 156 funds closed out of VRTX and 143 opened new positions — a net loss of 13 holders — while 617 trimmed existing stakes and 550 added.

The largest buyer was Capital International Investors, adding an estimated $858M. The largest seller was Fidelity Investments, cutting an estimated $1.3B.

  • 1,519 institutional investors held Vertex Pharmaceuticals (VRTX) as of Q3 2025, down from 1,559 in Q2 2025.
  • Funds reported $90.8B of Vertex Pharmaceuticals stock for Q3 2025, down 15% quarter-over-quarter.
  • 143 funds opened new Vertex Pharmaceuticals positions in Q3 2025 and 156 closed out, a net change of -13 holders.
  • The largest Vertex Pharmaceuticals buyer in Q3 2025 was Capital International Investors, an estimated $858M added.
  • The largest Vertex Pharmaceuticals seller in Q3 2025 was Fidelity Investments, an estimated $1.3B sold.

Based on aggregated 13F filings for Q3 2025.