Vertex Pharmaceuticals
VRTX
1,525 hedge funds and large institutions have $90.8B invested in Vertex Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 144 funds opening new positions, 554 increasing their positions, 616 reducing their positions, and 156 closing their positions.
59% more call options, than puts
Call options by funds: $846M | Put options by funds: $533M
8% less first-time investments, than exits
New positions opened: 144 | Existing positions closed: 156
2% less funds holding
Funds holding: 1,564 → 1,525 (-39)
3.23% less ownership
Funds ownership: 93.82% → 90.59% (-3.2%)
10% less repeat investments, than reductions
Existing positions increased: 554 | Existing positions reduced: 616
39% less capital inflows, than outflows
Capital inflows: $5.64B | Capital outflows: $9.28B
56% less funds holding in top 10
Funds holding in top 10: 16 → 7 (-9)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Capital International Investors
Los Angeles,
California
|
+$858M |
| 2 |
ClearBridge Investments
New York
|
+$467M |
| 3 |
JP Morgan Chase
New York
|
+$236M |
| 4 |
Assenagon Asset Management
Senningerberg,
Luxembourg
|
+$218M |
| 5 |
Capital Research Global Investors
Los Angeles,
California
|
+$186M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
-$1.3B |
| 2 |
Capital World Investors
Los Angeles,
California
|
-$1.18B |
| 3 |
Jennison Associates
New York
|
-$1.13B |
| 4 |
Edgewood Management
Greenwich,
Connecticut
|
-$404M |
| 5 |
Massachusetts Financial Services
Boston,
Massachusetts
|
-$326M |
VRTX Hedge Fund Activity: Q3 2025 in Review
1,525 of the 7,651 institutional investors tracked by Wall St. Rank reported a position in Vertex Pharmaceuticals (VRTX) for Q3 2025, worth a combined $90.8B — down 15% from $107B a quarter earlier.
Sellers outnumbered buyers: 156 funds closed out of VRTX and 144 opened new positions — a net loss of 12 holders — while 616 trimmed existing stakes and 554 added.
The largest buyer was Capital International Investors, adding an estimated $858M. The largest seller was Fidelity Investments, cutting an estimated $1.3B.
- 1,525 institutional investors held Vertex Pharmaceuticals (VRTX) as of Q3 2025, down from 1,564 in Q2 2025.
- Funds reported $90.8B of Vertex Pharmaceuticals stock for Q3 2025, down 15% quarter-over-quarter.
- 144 funds opened new Vertex Pharmaceuticals positions in Q3 2025 and 156 closed out, a net change of -12 holders.
- The largest Vertex Pharmaceuticals buyer in Q3 2025 was Capital International Investors, an estimated $858M added.
- The largest Vertex Pharmaceuticals seller in Q3 2025 was Fidelity Investments, an estimated $1.3B sold.
Based on aggregated 13F filings for Q3 2025.