|
1
|
Frazier Management
Seattle,
Washington
|
$21.8M
|
–
|
–
|
–
|
|
|
2
|
Novo Holdings A/S
Hellerup,
Denmark
|
$18.7M
|
-$1.43M
|
-190,000
|
-8%
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
$11.7M
|
-$844K
|
-111,853
|
-7%
|
|
|
4
|
BVF Inc
San Francisco,
California
|
$10.3M
|
–
|
–
|
–
|
|
|
5
|
Stonepine Capital Management
Bend,
Oregon
|
$6.81M
|
-$3.02K
|
-400
|
-0%
|
|
|
6
|
Franklin Resources
San Mateo,
California
|
$4.8M
|
+$4.42M
|
+586,400
|
New
|
|
|
7
|
Abingworth
London,
United Kingdom
|
$4.79M
|
–
|
–
|
–
|
|
|
8
|
Vanguard Group
Malvern,
Pennsylvania
|
$2.62M
|
+$37K
|
+4,906
|
+2%
|
|
|
9
|
EverPoint Asset Management
Stamford,
Connecticut
|
$2.49M
|
-$435K
|
-57,661
|
-16%
|
|
|
10
|
Marshall Wace
London,
United Kingdom
|
$1.6M
|
+$669K
|
+88,723
|
+83%
|
|
|
11
|
Sabby Management
Miami Beach,
Florida
|
$818K
|
-$5.86M
|
-777,342
|
-89%
|
|
|
12
|
DAFNA Capital Management
Los Angeles,
California
|
$666K
|
-$596K
|
-78,951
|
-49%
|
|
|
13
|
BlackRock Fund Advisors
San Francisco,
California
|
$522K
|
-$27K
|
-3,585
|
-5%
|
|
|
14
|
Oxford Asset Management
Oxford,
United Kingdom
|
$441K
|
-$158K
|
-20,916
|
-28%
|
|
|
15
|
Polar Capital
London,
United Kingdom
|
$409K
|
+$120K
|
+15,939
|
+47%
|
|
|
16
|
Millennium Management
New York
|
$372K
|
-$486K
|
-64,487
|
-59%
|
|
|
17
|
Nexthera Capital
New York
|
$368K
|
+$75.4K
|
+10,000
|
+29%
|
|
|
18
|
State Street
Boston,
Massachusetts
|
$351K
|
+$210K
|
+27,794
|
+184%
|
|
|
19
|
Northern Trust
Chicago,
Illinois
|
$333K
|
+$11.1K
|
+1,470
|
+4%
|
|
|
20
|
BlackRock Institutional Trust
San Francisco,
California
|
$324K
|
-$7.15K
|
-948
|
-2%
|
|
|
21
|
William Blair & Company
Chicago,
Illinois
|
$304K
|
+$196K
|
+26,000
|
+232%
|
|
|
22
|
Sphera Funds Management
Tel Aviv,
Israel
|
$264K
|
-$1.17M
|
-155,322
|
-83%
|
|
|
23
|
Geode Capital Management
Boston,
Massachusetts
|
$263K
|
+$6.03K
|
+799
|
+3%
|
|
|
24
|
Renaissance Technologies
New York
|
$245K
|
-$33.2K
|
-4,400
|
-13%
|
|
|
25
|
Canaan Partners VII
Westport,
Connecticut
|
$195K
|
–
|
–
|
–
|
|
