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SYBX

Synlogic
SYBX

Delisted

SYBX was delisted on the 20th of January, 2026.

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25 hedge funds and large institutions have $7.71M invested in Synlogic in 2025 Q4 according to their latest regulatory filings, with 5 funds opening new positions, 6 increasing their positions, 1 reducing their positions, and 3 closing their positions.

New
Increased
Maintained
Reduced
Closed

500% more repeat investments, than reductions

Existing positions increased: 6 | Existing positions reduced: 1

67% more first-time investments, than exits

New positions opened: 5 | Existing positions closed: 3

9% more funds holding

Funds holding: 23 → 25 (+2)

1.92% more ownership

Funds ownership: 56.89% → 58.81% (+1.9%)

31% less capital invested

Capital invested by funds: $11.1M → $7.71M (-$3.4M)

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
25
Holders Change
+2
Holders Change %
+8.7%
% of All Funds
0.3%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
5
Increased
6
Reduced
1
Closed
3
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Citadel Advisors
Citadel Advisors
Florida
+$169K
2
Renaissance Technologies
Renaissance Technologies
New York
+$69.1K
3
DS
DRW Securities
Illinois
+$36.5K
4
Jane Street
Jane Street
New York
+$22.5K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$17.4K

Top Sellers

Rank Fund Capital Flow
1
IC
Ikarian Capital
Texas
-$683
2
Jones Financial Companies
Jones Financial Companies
Missouri
-$35
3
Wells Fargo
Wells Fargo
California
-$8
4
Barclays
Barclays
United Kingdom
-$2
Name Holding Trade Value Shares
Change 		Change in
Stake
CCC
1
Cable Car Capital
California
$3.71M – – –
NMC
2
NEA Management Company
Maryland
$3.27M – – –
Vanguard Group
3
Vanguard Group
Pennsylvania
$225K +$6.89K +4,599 +2%
Citadel Advisors
4
Citadel Advisors
Florida
$159K +$169K +112,597 +388%
Renaissance Technologies
5
Renaissance Technologies
New York
$95.9K +$69.1K +46,117 +117%
Geode Capital Management
6
Geode Capital Management
Massachusetts
$80.2K +$5.96K +3,980 +6%
DS
7
DRW Securities
Illinois
$27.3K +$36.5K +24,363 New
IC
8
Ikarian Capital
Texas
$22.4K -$683 -456 -2%
BlackRock
9
BlackRock
New York
$22.1K – – –
Northern Trust
10
Northern Trust
Illinois
$21.8K – – –
Jane Street
11
Jane Street
New York
$16.8K +$22.5K +14,998 New
XT
12
XTX Topco
Cayman Islands
$16.1K +$4.83K +3,225 +29%
Susquehanna International Group
13
Susquehanna International Group
Pennsylvania
$13K +$17.4K +11,623 New
State Street
14
State Street
Massachusetts
$11.4K – – –
Fidelity Investments
15
Fidelity Investments
Massachusetts
$5.96K – – –
UBS Group
16
UBS Group
Switzerland
$2.83K +$3.79K +2,531 New
Morgan Stanley
17
Morgan Stanley
New York
$1.23K – – –
FHA
18
Flagship Harbor Advisors
Massachusetts
$1.16K +$1.55K +1,033 New
SS
19
SBI Securities
Japan
$115 – – –
Bank of America
20
Bank of America
North Carolina
$73 +$3 +2 +3%
BNP Paribas Financial Markets
21
BNP Paribas Financial Markets
France
$27 – – –
HNB
22
Hilltop National Bank
Wyoming
$22 – – –
Citigroup
23
Citigroup
New York
$1 – – –
DB
24
Danske Bank
Denmark
$1 – – –
JP Morgan Chase
25
JP Morgan Chase
New York
$1 – – –
1
2

SYBX Hedge Fund Activity: Q4 2025 in Review

25 of the 8,224 institutional investors tracked by Wall St. Rank reported a position in Synlogic (SYBX) for Q4 2025, worth a combined $7.71M — down 31% from $11.1M a quarter earlier.

Buyers outnumbered sellers: 5 funds opened new SYBX positions and 3 closed out — a net gain of 2 holders — while 6 added to existing stakes and 1 trimmed.

The largest buyer was Citadel Advisors, adding an estimated $169K. The largest seller was Ikarian Capital, cutting an estimated $683.

  • 25 institutional investors held Synlogic (SYBX) as of Q4 2025, up from 23 in Q3 2025.
  • Funds reported $7.71M of Synlogic stock for Q4 2025, down 31% quarter-over-quarter.
  • 5 funds opened new Synlogic positions in Q4 2025 and 3 closed out, a net change of +2 holders.
  • The largest Synlogic buyer in Q4 2025 was Citadel Advisors, an estimated $169K added.
  • The largest Synlogic seller in Q4 2025 was Ikarian Capital, an estimated $683 sold.

Based on aggregated 13F filings for Q4 2025.