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SYBX

Synlogic
SYBX

Delisted

SYBX was delisted on the 20th of January, 2026.

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51 hedge funds and large institutions have $25.5M invested in Synlogic in 2022 Q4 according to their latest regulatory filings, with 7 funds opening new positions, 13 increasing their positions, 9 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

44% more repeat investments, than reductions

Existing positions increased: 13 | Existing positions reduced: 9

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

0.57% less ownership

Funds ownership: 3.78% → 3.21% (-0.57%)

4% less funds holding

Funds holding: 53 → 51 (-2)

21% less capital invested

Capital invested by funds: $32.1M → $25.5M (-$6.61M)

22% less first-time investments, than exits

New positions opened: 7 | Existing positions closed: 9

Holders
51
Holders Change
-2
Holders Change %
-3.77%
% of All Funds
0.82%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
7
Increased
13
Reduced
9
Closed
9
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
+$59.7K
2
Envestnet Asset Management
Envestnet Asset Management
Illinois
+$46.9K
3
PAM
PVG Asset Management
Colorado
+$41.8K
4
Fidelity Investments
Fidelity Investments
Massachusetts
+$35.5K
5
Prudential Financial
Prudential Financial
New Jersey
+$24.6K

Top Sellers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
-$4.39M
2
Alyeska Investment Group
Alyeska Investment Group
Illinois
-$807K
3
UOC
UBS O'Connor
Illinois
-$442K
4
Renaissance Technologies
Renaissance Technologies
New York
-$15.6K
5
Citadel Advisors
Citadel Advisors
Florida
-$14K
Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$8.04M +$35.5K +2,907 +0.4%
O
2
OrbiMed
New York
$4.58M – – –
NMC
3
NEA Management Company
Maryland
$3.21M -$391 -32 -0%
Alyeska Investment Group
4
Alyeska Investment Group
Illinois
$2.05M -$807K -66,107 -27%
AVAI
5
Atlas Venture Associates IX
Massachusetts
$2.02M – – –
Vanguard Group
6
Vanguard Group
Pennsylvania
$1.71M +$647 +53 +0%
Morgan Stanley
7
Morgan Stanley
New York
$517K +$500 +41 +0.1%
SI
8
Sofinnova Investments
California
$437K – – –
LP
9
LMR Partners
United Kingdom
$391K – – –
BlackRock
10
BlackRock
New York
$332K +$5.2K +426 +1%
Geode Capital Management
11
Geode Capital Management
Massachusetts
$304K +$4.89K +401 +2%
HCA
12
Harbor Capital Advisors
Illinois
$237K -$5.49K -450 -2%
IC
13
Ikarian Capital
Texas
$233K – – –
BCM
14
Bridgeway Capital Management
Texas
$175K – – –
AICPI
15
ABG Innovation Capital Partners III
Hong Kong
$156K – – –
State Street
16
State Street
Massachusetts
$117K – – –
Two Sigma Advisers
17
Two Sigma Advisers
New York
$108K -$8.21K -673 -7%
Renaissance Technologies
18
Renaissance Technologies
New York
$73K -$15.6K -1,280 -17%
Millennium Management
19
Millennium Management
New York
$73K +$59.7K +4,895 +334%
Northern Trust
20
Northern Trust
Illinois
$71.3K – – –
Two Sigma Investments
21
Two Sigma Investments
New York
$62.3K -$9.81K -804 -13%
Envestnet Asset Management
22
Envestnet Asset Management
Illinois
$59.8K +$46.9K +3,841 +274%
Franklin Resources
23
Franklin Resources
California
$59.3K – – –
PAM
24
PVG Asset Management
Colorado
$53.4K +$41.8K +3,423 +272%
NFGH
25
Nan Fung Group Holdings
Hong Kong
$52.2K – – –
1
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SYBX Hedge Fund Activity: Q4 2022 in Review

51 of the 6,221 institutional investors tracked by Wall St. Rank reported a position in Synlogic (SYBX) for Q4 2022, worth a combined $25.5M — down 21% from $32.1M a quarter earlier.

Sellers outnumbered buyers: 9 funds closed out of SYBX and 7 opened new positions — a net loss of 2 holders — while 9 trimmed existing stakes and 13 added.

The largest buyer was Millennium Management, adding an estimated $59.7K. The largest seller was RA Capital Management, exiting entirely with an estimated $4.39M sold.

  • 51 institutional investors held Synlogic (SYBX) as of Q4 2022, down from 53 in Q3 2022.
  • Funds reported $25.5M of Synlogic stock for Q4 2022, down 21% quarter-over-quarter.
  • 7 funds opened new Synlogic positions in Q4 2022 and 9 closed out, a net change of -2 holders.
  • The largest Synlogic buyer in Q4 2022 was Millennium Management, an estimated $59.7K added.
  • The largest Synlogic seller in Q4 2022 was RA Capital Management, an estimated $4.39M sold.

Based on aggregated 13F filings for Q4 2022.