Synlogic
SYBX
SYBX was delisted on the 20th of January, 2026.
62 hedge funds and large institutions have $105M invested in Synlogic in 2021 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 16 increasing their positions, 13 reducing their positions, and 17 closing their positions.
23% more repeat investments, than reductions
Existing positions increased: 16 | Existing positions reduced: 13
0% more funds holding in top 10
Funds holding in top 10: 2 → 2 (0)
0.2% less ownership
Funds ownership: 4.34% → 4.14% (-0.2%)
10% less funds holding
Funds holding: 69 → 62 (-7)
22% less capital invested
Capital invested by funds: $134M → $105M (-$28.8M)
41% less first-time investments, than exits
New positions opened: 10 | Existing positions closed: 17
71% less call options, than puts
Call options by funds: $4K | Put options by funds: $14K
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
OM
Opaleye Management
Boston,
Massachusetts
|
+$2.2M |
| 2 |
Alyeska Investment Group
Chicago,
Illinois
|
+$1.19M |
| 3 |
Fidelity Investments
Boston,
Massachusetts
|
+$907K |
| 4 |
Millennium Management
New York
|
+$497K |
| 5 |
BCM
Bridgeway Capital Management
Houston,
Texas
|
+$259K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
LGM
Logos Global Management
San Francisco,
California
|
-$4.58M |
| 2 |
MS
Maven Securities
St Helier,
Jersey
|
-$1.27M |
| 3 |
IC
Ikarian Capital
Dallas,
Texas
|
-$790K |
| 4 |
GGHC
Gilder Gagnon Howe & Co
New York
|
-$506K |
| 5 |
MIM
Monashee Investment Management
Boston,
Massachusetts
|
-$458K |
SYBX Hedge Fund Activity: Q4 2021 in Review
62 of the 6,498 institutional investors tracked by Wall St. Rank reported a position in Synlogic (SYBX) for Q4 2021, worth a combined $105M — down 22% from $134M a quarter earlier.
Sellers outnumbered buyers: 17 funds closed out of SYBX and 10 opened new positions — a net loss of 7 holders — while 13 trimmed existing stakes and 16 added.
The largest buyer was Opaleye Management, opening a new position worth an estimated $2.2M. The largest seller was Logos Global Management, exiting entirely with an estimated $4.58M sold.
- 62 institutional investors held Synlogic (SYBX) as of Q4 2021, down from 69 in Q3 2021.
- Funds reported $105M of Synlogic stock for Q4 2021, down 22% quarter-over-quarter.
- 10 funds opened new Synlogic positions in Q4 2021 and 17 closed out, a net change of -7 holders.
- The largest Synlogic buyer in Q4 2021 was Opaleye Management, an estimated $2.2M added.
- The largest Synlogic seller in Q4 2021 was Logos Global Management, an estimated $4.58M sold.
Based on aggregated 13F filings for Q4 2021.