Synlogic
SYBX
SYBX was delisted on the 20th of January, 2026.
25 hedge funds and large institutions have $7.71M invested in Synlogic in 2025 Q4 according to their latest regulatory filings, with 5 funds opening new positions, 6 increasing their positions, 1 reducing their positions, and 3 closing their positions.
500% more repeat investments, than reductions
Existing positions increased: 6 | Existing positions reduced: 1
67% more first-time investments, than exits
New positions opened: 5 | Existing positions closed: 3
9% more funds holding
Funds holding: 23 → 25 (+2)
1.92% more ownership
Funds ownership: 56.89% → 58.81% (+1.9%)
31% less capital invested
Capital invested by funds: $11.1M → $7.71M (-$3.4M)
100% less funds holding in top 10
Funds holding in top 10: 1 → 0 (-1)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Citadel Advisors
Miami,
Florida
|
+$169K |
| 2 |
Renaissance Technologies
New York
|
+$69.1K |
| 3 |
DS
DRW Securities
Chicago,
Illinois
|
+$36.5K |
| 4 |
Jane Street
New York
|
+$22.5K |
| 5 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
+$17.4K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
IC
Ikarian Capital
Dallas,
Texas
|
-$683 |
| 2 |
Jones Financial Companies
Des Peres,
Missouri
|
-$35 |
| 3 |
Wells Fargo
San Francisco,
California
|
-$8 |
| 4 |
Barclays
London,
United Kingdom
|
-$2 |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
26
Jones Financial Companies
Des Peres,
Missouri
| – | -$35 | -20 | Closed |
|
|
27
Wells Fargo
San Francisco,
California
| – | -$8 | -5 | Closed |
|
|
28
Barclays
London,
United Kingdom
| – | -$2 | -1 | Closed |
|
SYBX Hedge Fund Activity: Q4 2025 in Review
25 of the 8,225 institutional investors tracked by Wall St. Rank reported a position in Synlogic (SYBX) for Q4 2025, worth a combined $7.71M — down 31% from $11.1M a quarter earlier.
Buyers outnumbered sellers: 5 funds opened new SYBX positions and 3 closed out — a net gain of 2 holders — while 6 added to existing stakes and 1 trimmed.
The largest buyer was Citadel Advisors, adding an estimated $169K. The largest seller was Ikarian Capital, cutting an estimated $683.
- 25 institutional investors held Synlogic (SYBX) as of Q4 2025, up from 23 in Q3 2025.
- Funds reported $7.71M of Synlogic stock for Q4 2025, down 31% quarter-over-quarter.
- 5 funds opened new Synlogic positions in Q4 2025 and 3 closed out, a net change of +2 holders.
- The largest Synlogic buyer in Q4 2025 was Citadel Advisors, an estimated $169K added.
- The largest Synlogic seller in Q4 2025 was Ikarian Capital, an estimated $683 sold.
Based on aggregated 13F filings for Q4 2025.