Synlogic
SYBX
SYBX was delisted on the 20th of January, 2026.
52 hedge funds and large institutions have $102M invested in Synlogic in 2022 Q1 according to their latest regulatory filings, with 5 funds opening new positions, 11 increasing their positions, 15 reducing their positions, and 15 closing their positions.
0% more funds holding in top 10
Funds holding in top 10: 2 → 2 (0)
0.09% less ownership
Funds ownership: 4.14% → 4.05% (-0.09%)
2% less capital invested
Capital invested by funds: $105M → $102M (-$2.36M)
16% less funds holding
Funds holding: 62 → 52 (-10)
26% less call options, than puts
Call options by funds: $14K | Put options by funds: $19K
27% less repeat investments, than reductions
Existing positions increased: 11 | Existing positions reduced: 15
67% less first-time investments, than exits
New positions opened: 5 | Existing positions closed: 15
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
OM
Opaleye Management
Boston,
Massachusetts
|
+$279K |
| 2 |
Fidelity Investments
Boston,
Massachusetts
|
+$162K |
| 3 |
Alyeska Investment Group
Chicago,
Illinois
|
+$154K |
| 4 |
Geode Capital Management
Boston,
Massachusetts
|
+$105K |
| 5 |
State Street
Boston,
Massachusetts
|
+$86.2K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Two Sigma Advisers
New York
|
-$453K |
| 2 |
Two Sigma Investments
New York
|
-$449K |
| 3 |
Millennium Management
New York
|
-$448K |
| 4 |
TCM
Triumph Capital Management
Denver,
Colorado
|
-$202K |
| 5 |
HCA
Harbor Capital Advisors
Chicago,
Illinois
|
-$171K |
SYBX Hedge Fund Activity: Q1 2022 in Review
52 of the 6,340 institutional investors tracked by Wall St. Rank reported a position in Synlogic (SYBX) for Q1 2022, worth a combined $102M — down 2.2% from $105M a quarter earlier.
Sellers outnumbered buyers: 15 funds closed out of SYBX and 5 opened new positions — a net loss of 10 holders — while 15 trimmed existing stakes and 11 added.
The largest buyer was Opaleye Management, adding an estimated $279K. The largest seller was Two Sigma Advisers, cutting an estimated $453K.
- 52 institutional investors held Synlogic (SYBX) as of Q1 2022, down from 62 in Q4 2021.
- Funds reported $102M of Synlogic stock for Q1 2022, down 2.2% quarter-over-quarter.
- 5 funds opened new Synlogic positions in Q1 2022 and 15 closed out, a net change of -10 holders.
- The largest Synlogic buyer in Q1 2022 was Opaleye Management, an estimated $279K added.
- The largest Synlogic seller in Q1 2022 was Two Sigma Advisers, an estimated $453K sold.
Based on aggregated 13F filings for Q1 2022.