|
1
|
Vivo Capital
Palo Alto,
California
|
$283M
|
–
|
–
|
–
|
|
|
2
|
Janus Henderson Group
London,
|
$233M
|
+$57.4M
|
+1,107,166
|
+27%
|
|
|
3
|
Nantahala Capital Management
New Canaan,
Connecticut
|
$177M
|
+$34.1M
|
+658,518
|
+20%
|
|
|
4
|
Adage Capital Partners
Boston,
Massachusetts
|
$125M
|
-$28.3M
|
-546,170
|
-16%
|
|
|
5
|
Avoro Capital Advisors
New York
|
$113M
|
+$17.8M
|
+344,000
|
+16%
|
|
|
6
|
|
$90.3M
|
-$105K
|
-2,027
|
-0.1%
|
|
|
7
|
Vanguard Group
Malvern,
Pennsylvania
|
$84.7M
|
+$15.7M
|
+303,806
|
+19%
|
|
|
8
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$73.3M
|
+$16.6M
|
+321,223
|
+25%
|
|
|
9
|
Commodore Capital
New York
|
$68.5M
|
+$13.7M
|
+265,000
|
+21%
|
|
|
10
|
Perceptive Advisors
New York
|
$67.5M
|
-$88.3M
|
-1,703,936
|
-53%
|
|
|
11
|
Carlyle Group
Washington,
District of Columbia
|
$61.8M
|
-$140M
|
-2,695,916
|
-66%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$60.5M
|
+$10.6M
|
+204,850
|
+18%
|
|
|
13
|
Vestal Point Capital
New York
|
$47.6M
|
+$17.6M
|
+340,000
|
+47%
|
|
|
14
|
Citadel Advisors
Miami,
Florida
|
$43.7M
|
+$49.3M
|
+950,670
|
+4,373%
|
|
|
15
|
Holocene Advisors
New York
|
$42.9M
|
+$18.7M
|
+361,103
|
+61%
|
|
|
16
|
Westfield Capital Management
Boston,
Massachusetts
|
$39.6M
|
+$20M
|
+385,752
|
+78%
|
|
|
17
|
Pictet Asset Management
Carouge,
Switzerland
|
$38.3M
|
+$14.3M
|
+276,225
|
+48%
|
|
|
18
|
Fidelity Investments
Boston,
Massachusetts
|
$36.5M
|
+$7.65M
|
+147,653
|
+22%
|
|
|
19
|
Wellington Management Group
Boston,
Massachusetts
|
$35.2M
|
+$5.13M
|
+99,095
|
+15%
|
|
|
20
|
Sofinnova Investments
Menlo Park,
California
|
$34M
|
+$8.86M
|
+170,904
|
+29%
|
|
|
21
|
Frazier Life Sciences Management
Palo Alto,
California
|
$31.4M
|
-$9.15M
|
-176,508
|
-20%
|
|
|
22
|
Geode Capital Management
Boston,
Massachusetts
|
$26.9M
|
+$3.05M
|
+58,823
|
+11%
|
|
|
23
|
Emerald Advisers
Leola,
Pennsylvania
|
$26.1M
|
+$13.9M
|
+267,585
|
+85%
|
|
|
24
|
TCG Crossover Management
Palo Alto,
California
|
$24.7M
|
–
|
–
|
–
|
|
|
25
|
Artia Global Partners
Miami,
Florida
|
$22.2M
|
+$11.4M
|
+220,000
|
+80%
|
|
