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SION

Sionna Therapeutics
SION

47 hedge funds and large institutions have $434M invested in Sionna Therapeutics in 2025 Q1 according to their latest regulatory filings, with 47 funds opening new positions, increasing their positions, reducing their positions, and closing their positions.

New
Increased
Maintained
Reduced
Closed

94.04% more ownership

Funds ownership: 0% → 94.04% (+94%)

Holders
47
Holders Change
+47
Holders Change %
–
% of All Funds
0.63%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
% of All Funds
0.03%
New
47
Increased
–
Reduced
–
Closed
–
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
+$171M
2
TGA
TPG GP A
Texas
+$109M
3
O
OrbiMed
New York
+$60.5M
4
AVLSA
Atlas Venture Life Science Advisors
Massachusetts
+$60.4M
5
Viking Global Investors
Viking Global Investors
Connecticut
+$48.2M

Top Sellers

No sellers this quarter
Name Holding Trade Value Shares
Change 		Change in
Stake
CP
26
CenterBook Partners
Connecticut
$1.2M +$1.87M +114,284 New
SCM
27
Silverarc Capital Management
Massachusetts
$1.19M +$1.86M +114,138 New
RSCM
28
Rock Springs Capital Management
Maryland
$1.04M +$1.62M +99,429 New
WP
29
Woodline Partners
California
$837K +$1.31M +80,000 New
Charles Schwab
30
Charles Schwab
California
$676K +$1.06M +64,644 New
Goldman Sachs
31
Goldman Sachs
New York
$667K +$1.04M +63,741 New
Prudential Financial
32
Prudential Financial
New Jersey
$659K +$1.03M +63,000 New
SC
33
Stempoint Capital
New York
$628K +$980K +60,000 New
TD Asset Management
34
TD Asset Management
Ontario, Canada
$579K +$905K +55,366 New
Holocene Advisors
35
Holocene Advisors
New York
$523K +$817K +50,000 New
Squarepoint
36
Squarepoint
New York
$355K +$555K +33,964 New
Manulife (Manufacturers Life Insurance)
37
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$351K +$548K +33,549 New
Northern Trust
38
Northern Trust
Illinois
$281K +$438K +26,822 New
ACM
39
Aster Capital Management
United Arab Emirates
$203K +$241K +14,757 New
State Street
40
State Street
Massachusetts
$151K +$235K +14,400 New
Balyasny Asset Management
41
Balyasny Asset Management
Illinois
$137K +$213K +13,060 New
Marshall Wace
42
Marshall Wace
United Kingdom
$127K +$199K +12,188 New
Two Sigma Investments
43
Two Sigma Investments
New York
$123K +$191K +11,715 New
UBS Group
44
UBS Group
Switzerland
$117K +$182K +11,146 New
Bank of America
45
Bank of America
North Carolina
$91.4K +$143K +8,739 New
Morgan Stanley
46
Morgan Stanley
New York
$41.2K +$64.4K +3,939 New
Royal Bank of Canada
47
Royal Bank of Canada
Ontario, Canada
$6K +$10.1K +618 New
1
2

SION Hedge Fund Activity: Q1 2025 in Review

47 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Sionna Therapeutics (SION) for Q1 2025, worth a combined $434M.

Buyers outnumbered sellers: 47 funds opened new SION positions and 0 closed out — a net gain of 47 holders — while 0 added to existing stakes and 0 trimmed.

The largest buyer was RA Capital Management, opening a new position worth an estimated $171M.

  • 47 institutional investors held Sionna Therapeutics (SION) as of Q1 2025, up from 0 in Q4 2024.
  • Funds reported $434M of Sionna Therapeutics stock for Q1 2025.
  • 47 funds opened new Sionna Therapeutics positions in Q1 2025 and 0 closed out, a net change of +47 holders.
  • The largest Sionna Therapeutics buyer in Q1 2025 was RA Capital Management, an estimated $171M added.

Based on aggregated 13F filings for Q1 2025.