Two Sigma Investments
SION

Two Sigma Investments’s Sionna Therapeutics SION Stock Holding History

Two Sigma Investments’s Portfolio SION Stock Details SION Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$220K Sell
5,500
-900
-14% -$34.3K ﹤0.01% 4246
2025
Q4 		$263K Buy
+6,400
New +$243K ﹤0.01% 3640
2025
Q2 		– Sell
-11,715
Closed -$123K – 3645
2025
Q1 		$123K Buy
+11,715
New +$191K ﹤0.01% 2939

Other funds holding SION

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGA
TPG GP A Fort Worth, Texas $3.68B AUM 14.99% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
Viking Global Investors
Viking Global Investors Stamford, Connecticut $35.7B AUM 21.3% 1-Year Est. Return
AVLSA
Atlas Venture Life Science Advisors Cambridge, Massachusetts $790M AUM 223.66% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
Jennison Associates
Jennison Associates New York $145B AUM 34.61% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return

Two Sigma Investments's SION Position: Q1 2026 in Review

Two Sigma Investments reduced its Sionna Therapeutics (SION) stake by 14% in Q1 2026, selling an estimated $34.3K and leaving 5,500 shares worth $220K. The position accounts for ﹤0.01% of the portfolio, ranked #4246.

Two Sigma Investments first reported a position in SION in Q1 2025 and has held it in 3 quarters since. The position peaked at $263K in Q4 2025. 122 funds tracked by Wall St. Rank hold SION as of Q1 2026.

  • Two Sigma Investments held 5,500 shares of Sionna Therapeutics worth $220K as of Q1 2026.
  • Two Sigma Investments sold 900 Sionna Therapeutics shares in Q1 2026, an estimated $34.3K.
  • Sionna Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4246 holding.
  • Two Sigma Investments first reported a position in Sionna Therapeutics in Q1 2025 and has held it in 3 quarters since.
  • Two Sigma Investments's Sionna Therapeutics position peaked at $263K in Q4 2025.
  • 122 funds tracked by Wall St. Rank held Sionna Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.