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SION

Sionna Therapeutics
SION

122 hedge funds and large institutions have $1.82B invested in Sionna Therapeutics in 2026 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 40 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

256% more first-time investments, than exits

New positions opened: 32 | Existing positions closed: 9

33% more repeat investments, than reductions

Existing positions increased: 40 | Existing positions reduced: 30

21% more funds holding

Funds holding: 101 → 122 (+21)

14% more funds holding in top 10

Funds holding in top 10: 7 → 8 (+1)

2.43% more ownership

Funds ownership: 98.48% → 100.91% (+2.4%)

0% more capital invested

Capital invested by funds: $1.81B → $1.82B (+$7.17M)

Holders
122
Holders Change
+21
Holders Change %
+20.79%
% of All Funds
1.5%
Holding in Top 10
8
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+14.29%
% of All Funds
0.1%
New
32
Increased
40
Reduced
30
Closed
9
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Jennison Associates
Jennison Associates
New York
+$12.8M
2
SCM
Sio Capital Management
New York
+$11.2M
3
CS
Candriam SCA
Luxembourg
+$9.04M
4
JP Morgan Chase
JP Morgan Chase
New York
+$8.9M
5
Goldman Sachs
Goldman Sachs
New York
+$8.66M

Top Sellers

Rank Fund Capital Flow
1
PA
Perceptive Advisors
New York
-$19.9M
2
Aberdeen Group
Aberdeen Group
United Kingdom
-$10.5M
3
TGA
TPG GP A
Texas
-$9.54M
4
Invesco
Invesco
Georgia
-$3.83M
5
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$2.86M
Name Holding Trade Value Shares
Change 		Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$397M – – –
TGA
2
TPG GP A
Texas
$260M -$9.54M -250,000 -4%
O
3
OrbiMed
New York
$142M -$1.18M -30,953 -0.9%
Viking Global Investors
4
Viking Global Investors
Connecticut
$128M – – –
AVLSA
5
Atlas Venture Life Science Advisors
Massachusetts
$120M – – –
ES
6
Enavate Sciences
California
$99.3M – – –
Jennison Associates
7
Jennison Associates
New York
$58.2M +$12.8M +335,942 +30%
JP Morgan Chase
8
JP Morgan Chase
New York
$53.7M +$8.9M +233,195 +19%
BlackRock
9
BlackRock
New York
$52M +$163K +4,268 +0.3%
Citadel Advisors
10
Citadel Advisors
Florida
$46.8M +$3.04M +79,606 +7%
VCM
11
Vanguard Capital Management
Pennsylvania
$41.3M +$39.3M +1,029,497 New
DM
12
Deerfield Management
New York
$38.9M – – –
T. Rowe Price Associates
13
T. Rowe Price Associates
Maryland
$30.3M -$2.86M -74,997 -9%
State Street
14
State Street
Massachusetts
$30.3M +$2.4M +62,832 +9%
PA
15
Perceptive Advisors
New York
$26.4M -$19.9M -520,659 -44%
EAM
16
Eventide Asset Management
Massachusetts
$25.9M +$247K +6,485 +1%
Aberdeen Group
17
Aberdeen Group
United Kingdom
$22.6M -$10.5M -275,785 -33%
BBA
18
Baker Bros. Advisors
New York
$16M – – –
Geode Capital Management
19
Geode Capital Management
Massachusetts
$15.6M +$375K +9,830 +3%
SL
20
Siren LLC
Connecticut
$12M – – –
SCM
21
Sio Capital Management
New York
$11.8M +$11.2M +294,340 New
SCM
22
Soleus Capital Management
Connecticut
$11.8M +$954K +25,000 +9%
Goldman Sachs
23
Goldman Sachs
New York
$10.6M +$8.66M +226,905 +626%
Ensign Peak Advisors
24
Ensign Peak Advisors
Utah
$10.2M +$6.71M +175,774 +220%
CS
25
Candriam SCA
Luxembourg
$9.49M +$9.04M +236,813 New
1
2 3 4 5

SION Hedge Fund Activity: Q1 2026 in Review

122 of the 8,127 institutional investors tracked by Wall St. Rank reported a position in Sionna Therapeutics (SION) for Q1 2026, worth a combined $1.82B — up 0.4% from $1.81B a quarter earlier.

Buyers outnumbered sellers: 32 funds opened new SION positions and 9 closed out — a net gain of 23 holders — while 40 added to existing stakes and 30 trimmed.

The largest buyer was Jennison Associates, adding an estimated $12.8M. The largest seller was Perceptive Advisors, cutting an estimated $19.9M.

  • 122 institutional investors held Sionna Therapeutics (SION) as of Q1 2026, up from 101 in Q4 2025.
  • Funds reported $1.82B of Sionna Therapeutics stock for Q1 2026, up 0.4% quarter-over-quarter.
  • 32 funds opened new Sionna Therapeutics positions in Q1 2026 and 9 closed out, a net change of +23 holders.
  • The largest Sionna Therapeutics buyer in Q1 2026 was Jennison Associates, an estimated $12.8M added.
  • The largest Sionna Therapeutics seller in Q1 2026 was Perceptive Advisors, an estimated $19.9M sold.

Based on aggregated 13F filings for Q1 2026.