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Rhythm Pharmaceuticals
RYTM

279 hedge funds and large institutions have $7.8B invested in Rhythm Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 57 funds opening new positions, 106 increasing their positions, 89 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed

43% more first-time investments, than exits

New positions opened: 57 | Existing positions closed: 40

41% more call options, than puts

Call options by funds: $45.9M | Put options by funds: $32.5M

19% more repeat investments, than reductions

Existing positions increased: 106 | Existing positions reduced: 89

8% more capital invested

Capital invested by funds: $7.2B → $7.8B (+$598M)

6% more funds holding

Funds holding: 264 → 279 (+15)

2.45% more ownership

Funds ownership: 106.73% → 109.17% (+2.4%)

0% more funds holding in top 10

Funds holding in top 10: 10 → 10 (0)

Holders
279
Holders Change
+15
Holders Change %
+5.68%
% of All Funds
3.39%
Holding in Top 10
10
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
57
Increased
106
Reduced
89
Closed
40
Calls
$45.9M
Puts
$32.5M
Net Calls
+$13.5M
Net Calls Change
-$21.7M

Top Buyers

1
Vanguard Group
Vanguard Group
Pennsylvania
+$129M
2
RCM
RA Capital Management
Massachusetts
+$105M
3
Jennison Associates
Jennison Associates
New York
+$53.8M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
+$45.6M
5
Capital Research Global Investors
Capital Research Global Investors
California
+$41M

Top Sellers

1
Alkeon Capital Management
Alkeon Capital Management
New York
-$103M
2
Primecap Management
Primecap Management
California
-$83.2M
3
Fidelity Investments
Fidelity Investments
Massachusetts
-$46.6M
4
Voloridge Investment Management
Voloridge Investment Management
Florida
-$32.6M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
-$29.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
VRS
151
Virginia Retirement Systems
Virginia
$985K +$265K +2,500 +37%
HT
152
Headlands Technologies
Illinois
$924K +$916K +8,632 New
Teacher Retirement System of Texas
153
Teacher Retirement System of Texas
Texas
$895K -$488K -4,601 -36%
Allianz Asset Management
154
Allianz Asset Management
Germany
$856K -$435K -4,100 -34%
BG
155
Bellevue Group
Switzerland
$803K -$164K -1,549 -17%
LWL
156
Leo Wealth LLC
Texas
$744K -$97.1K -915 -12%
JF
157
Jump Financial
Illinois
$723K +$717K +6,759 New
EOJOAM
158
E. Ohman J:or Asset Management
Sweden
$705K -$172K -1,624 -20%
Principal Financial Group
159
Principal Financial Group
Iowa
$663K -$679K -6,400 -51%
Acadian Asset Management
160
Acadian Asset Management
Massachusetts
$652K +$648K +6,105 New
ETC
161
Exchange Traded Concepts
Oklahoma
$651K -$32.5K -306 -5%
VIA
162
Virtus Investment Advisers
Connecticut
$644K -$110K -1,035 -15%
Canada Life
163
Canada Life
Manitoba, Canada
$621K -$912K -8,598 -60%
LCM
164
Legato Capital Management
California
$613K +$607K +5,723 New
JRP
165
Jasper Ridge Partners
California
$604K – – –
QC
166
Quantedge Capital
Singapore
$599K -$1.29M -12,200 -69%
Public Employees Retirement Association of Colorado
167
Public Employees Retirement Association of Colorado
Colorado
$585K – – –
LPL Financial
168
LPL Financial
California
$581K +$152K +1,437 +36%
AA
169
AlphaCentric Advisors
Puerto Rico
$541K +$536K +5,052 New
VCM
170
Voleon Capital Management
California
$538K -$2.32M -21,872 -81%
TSS
171
Two Sigma Securities
New York
$529K +$524K +4,943 New
GAM
172
Gotham Asset Management
New York
$519K -$424 -4 -0.1%
PR
173
PSP Research
Pennsylvania
$507K +$503K +4,738 New
PNC Financial Services Group
174
PNC Financial Services Group
Pennsylvania
$499K +$46.9K +442 +10%
CM
175
Caption Management
Oklahoma
$494K +$489K +4,614 New
5 6
7
8 9

RYTM Hedge Fund Activity: Q4 2025 in Review

279 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Rhythm Pharmaceuticals (RYTM) for Q4 2025, worth a combined $7.8B — up 8.3% from $7.2B a quarter earlier.

Buyers outnumbered sellers: 57 funds opened new RYTM positions and 40 closed out — a net gain of 17 holders — while 106 added to existing stakes and 89 trimmed.

The largest buyer was Vanguard Group, adding an estimated $129M. The largest seller was Alkeon Capital Management, exiting entirely with an estimated $103M sold.

  • 279 institutional investors held Rhythm Pharmaceuticals (RYTM) as of Q4 2025, up from 264 in Q3 2025.
  • Funds reported $7.8B of Rhythm Pharmaceuticals stock for Q4 2025, up 8.3% quarter-over-quarter.
  • 57 funds opened new Rhythm Pharmaceuticals positions in Q4 2025 and 40 closed out, a net change of +17 holders.
  • The largest Rhythm Pharmaceuticals buyer in Q4 2025 was Vanguard Group, an estimated $129M added.
  • The largest Rhythm Pharmaceuticals seller in Q4 2025 was Alkeon Capital Management, an estimated $103M sold.

Based on aggregated 13F filings for Q4 2025.