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Rhythm Pharmaceuticals
RYTM

279 hedge funds and large institutions have $7.8B invested in Rhythm Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 57 funds opening new positions, 106 increasing their positions, 89 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed

43% more first-time investments, than exits

New positions opened: 57 | Existing positions closed: 40

41% more call options, than puts

Call options by funds: $45.9M | Put options by funds: $32.5M

19% more repeat investments, than reductions

Existing positions increased: 106 | Existing positions reduced: 89

8% more capital invested

Capital invested by funds: $7.2B → $7.8B (+$598M)

6% more funds holding

Funds holding: 264 → 279 (+15)

2.45% more ownership

Funds ownership: 106.73% → 109.17% (+2.4%)

0% more funds holding in top 10

Funds holding in top 10: 10 → 10 (0)

Holders
279
Holders Change
+15
Holders Change %
+5.68%
% of All Funds
3.39%
Holding in Top 10
10
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
57
Increased
106
Reduced
89
Closed
40
Calls
$45.9M
Puts
$32.5M
Net Calls
+$13.5M
Net Calls Change
-$21.7M

Top Buyers

1
Vanguard Group
Vanguard Group
Pennsylvania
+$129M
2
RCM
RA Capital Management
Massachusetts
+$105M
3
Jennison Associates
Jennison Associates
New York
+$53.8M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
+$45.6M
5
Capital Research Global Investors
Capital Research Global Investors
California
+$41M

Top Sellers

1
Alkeon Capital Management
Alkeon Capital Management
New York
-$103M
2
Primecap Management
Primecap Management
California
-$83.2M
3
Fidelity Investments
Fidelity Investments
Massachusetts
-$46.6M
4
Voloridge Investment Management
Voloridge Investment Management
Florida
-$32.6M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
-$29.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
WCM
126
Wedge Capital Management
North Carolina
$2.06M -$318K -2,997 -13%
AAM
127
Advisors Asset Management
Colorado
$1.98M +$461K +4,346 +31%
CAPTRUST Financial Advisors
128
CAPTRUST Financial Advisors
North Carolina
$1.96M +$7.11K +67 +0.4%
Handelsbanken Fonder
129
Handelsbanken Fonder
Sweden
$1.88M +$212K +2,000 +13%
ASRS
130
Arizona State Retirement System
Arizona
$1.69M +$15.7K +148 +0.9%
State Board of Administration of Florida Retirement System
131
State Board of Administration of Florida Retirement System
Florida
$1.57M – – –
PFSRSONJ
132
Police & Firemen's Retirement System of New Jersey
New Jersey
$1.52M -$44.9K -423 -3%
Stifel Financial
133
Stifel Financial
Missouri
$1.42M -$128K -1,208 -8%
Nisa Investment Advisors
134
Nisa Investment Advisors
Missouri
$1.41M -$12.2K -115 -0.9%
Citigroup
135
Citigroup
New York
$1.36M -$38.2K -360 -3%
ProShare Advisors
136
ProShare Advisors
Maryland
$1.35M +$140K +1,323 +12%
GC
137
Guggenheim Capital
Illinois
$1.33M +$1.07M +10,116 +443%
SO
138
STRS Ohio
Ohio
$1.28M -$297K -2,800 -19%
KK
139
KLP Kapitalforvaltning
Norway
$1.28M +$106K +1,000 +9%
Rockefeller Capital Management
140
Rockefeller Capital Management
New York
$1.26M +$308K +2,903 +33%
SG Americas Securities
141
SG Americas Securities
New York
$1.26M -$829K -7,813 -40%
DnB Asset Management
142
DnB Asset Management
Norway
$1.19M +$598K +5,635 +102%
HWAM
143
Hennion & Walsh Asset Management
New Jersey
$1.17M -$3.59M -33,823 -76%
CUAMC
144
China Universal Asset Management Company
China
$1.16M -$81.4K -767 -7%
XT
145
XTX Topco
Cayman Islands
$1.12M +$1.11M +10,433 New
KOCAA
146
Knights of Columbus Asset Advisors
Connecticut
$1.1M +$1.09M +10,314 New
CFS
147
Cannon Financial Strategists
Georgia
$1.07M – – –
TFA
148
Toth Financial Advisory
Virginia
$1.07M – – –
Man Group
149
Man Group
United Kingdom
$1.02M -$12.7M -119,772 -93%
FAM
150
Fred Alger Management
New York
$996K -$322K -3,034 -25%
4 5
6
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RYTM Hedge Fund Activity: Q4 2025 in Review

279 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Rhythm Pharmaceuticals (RYTM) for Q4 2025, worth a combined $7.8B — up 8.3% from $7.2B a quarter earlier.

Buyers outnumbered sellers: 57 funds opened new RYTM positions and 40 closed out — a net gain of 17 holders — while 106 added to existing stakes and 89 trimmed.

The largest buyer was Vanguard Group, adding an estimated $129M. The largest seller was Alkeon Capital Management, exiting entirely with an estimated $103M sold.

  • 279 institutional investors held Rhythm Pharmaceuticals (RYTM) as of Q4 2025, up from 264 in Q3 2025.
  • Funds reported $7.8B of Rhythm Pharmaceuticals stock for Q4 2025, up 8.3% quarter-over-quarter.
  • 57 funds opened new Rhythm Pharmaceuticals positions in Q4 2025 and 40 closed out, a net change of +17 holders.
  • The largest Rhythm Pharmaceuticals buyer in Q4 2025 was Vanguard Group, an estimated $129M added.
  • The largest Rhythm Pharmaceuticals seller in Q4 2025 was Alkeon Capital Management, an estimated $103M sold.

Based on aggregated 13F filings for Q4 2025.