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Rhythm Pharmaceuticals
RYTM

Overview Fund Activity

227 hedge funds and large institutions have $3.42B invested in Rhythm Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 45 funds opening new positions, 85 increasing their positions, 69 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
227
Holders Change
+24
Holders Change %
+11.82%
% of All Funds
3.08%
Holding in Top 10
7
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-36.36%
% of All Funds
0.1%
New
45
Increased
85
Reduced
69
Closed
20
Calls
$21.5M
Puts
$3.46M
Net Calls
+$18M
Net Calls Change
-$6.98M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$83.4M
2
Westfield Capital Management
Westfield Capital Management
Massachusetts
+$71M
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$27.2M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$23.9M
5
SL
Siren LLC
Connecticut
+$14.7M

Top Sellers

1
FLSM
Frazier Life Sciences Management
California
-$63.1M
2
PA
Perceptive Advisors
New York
-$60M
3
PCH
Polar Capital Holdings
United Kingdom
-$53M
4
Primecap Management
Primecap Management
California
-$41.5M
5
BBA
Baker Bros. Advisors
New York
-$25.4M
Name Holding Trade Value Shares
Change 		Shares
Change %
HS
101
HighVista Strategies
Massachusetts
$1.86M -$126K -2,387 -6%
IIM
102
INTECH Investment Management
Florida
$1.8M +$307K +5,801 +21%
SC
103
Stempoint Capital
New York
$1.79M -$9.23M -174,200 -84%
State of Wisconsin Investment Board
104
State of Wisconsin Investment Board
Wisconsin
$1.75M +$40.4K +763 +2%
MIM
105
MetLife Investment Management
New Jersey
$1.72M -$57.4K -1,084 -3%
SEI Investments
106
SEI Investments
Pennsylvania
$1.72M -$60.4K -1,141 -3%
XT
107
XTX Topco
Cayman Islands
$1.59M +$1.18M +22,344 +294%
Tudor Investment Corp
108
Tudor Investment Corp
Connecticut
$1.56M +$756K +14,268 +94%
CF
109
Corebridge Financial
Texas
$1.42M -$21.1K -399 -1%
DFCM
110
Dark Forest Capital Management
Puerto Rico
$1.35M +$1.07M +20,198 +388%
Squarepoint
111
Squarepoint
New York
$1.29M +$1.29M +24,413 New
Wellington Management Group
112
Wellington Management Group
Massachusetts
$1.25M -$106K -1,997 -8%
Assenagon Asset Management
113
Assenagon Asset Management
Luxembourg
$1.18M +$1.18M +22,192 New
EGM
114
Engineers Gate Manager
New York
$1.16M +$143K +2,700 +14%
SG Americas Securities
115
SG Americas Securities
New York
$1.04M +$1.04M +19,667 New
FRM
116
Fox Run Management
Connecticut
$1.02M +$1.02M +19,172 New
SO
117
STRS Ohio
Ohio
$980K +$111K +2,100 +13%
Stifel Financial
118
Stifel Financial
Missouri
$979K -$54.5K -1,029 -5%
Schroder Investment Management Group
119
Schroder Investment Management Group
United Kingdom
$965K +$965K +17,618 New
Ensign Peak Advisors
120
Ensign Peak Advisors
Utah
$935K – – –
CAPTRUST Financial Advisors
121
CAPTRUST Financial Advisors
North Carolina
$919K +$919K +17,357 New
SC
122
SummitTX Capital
Texas
$919K +$919K +17,343 New
Victory Capital Management
123
Victory Capital Management
Texas
$918K +$9.22K +174 +1%
JFG
124
Jefferies Financial Group
New York
$906K +$906K +17,100 New
QCM
125
Quantinno Capital Management
New York
$905K +$51.2K +966 +6%
3 4
5
6 7