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Rhythm Pharmaceuticals
RYTM

279 hedge funds and large institutions have $7.8B invested in Rhythm Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 57 funds opening new positions, 106 increasing their positions, 89 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed

43% more first-time investments, than exits

New positions opened: 57 | Existing positions closed: 40

41% more call options, than puts

Call options by funds: $45.9M | Put options by funds: $32.5M

19% more repeat investments, than reductions

Existing positions increased: 106 | Existing positions reduced: 89

8% more capital invested

Capital invested by funds: $7.2B → $7.8B (+$598M)

6% more funds holding

Funds holding: 264 → 279 (+15)

2.45% more ownership

Funds ownership: 106.73% → 109.17% (+2.4%)

0% more funds holding in top 10

Funds holding in top 10: 10 → 10 (0)

Holders
279
Holders Change
+15
Holders Change %
+5.68%
% of All Funds
3.39%
Holding in Top 10
10
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
57
Increased
106
Reduced
89
Closed
40
Calls
$45.9M
Puts
$32.5M
Net Calls
+$13.5M
Net Calls Change
-$21.7M

Top Buyers

1
Vanguard Group
Vanguard Group
Pennsylvania
+$129M
2
RCM
RA Capital Management
Massachusetts
+$105M
3
Jennison Associates
Jennison Associates
New York
+$53.8M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
+$45.6M
5
Capital Research Global Investors
Capital Research Global Investors
California
+$41M

Top Sellers

1
Alkeon Capital Management
Alkeon Capital Management
New York
-$103M
2
Primecap Management
Primecap Management
California
-$83.2M
3
Fidelity Investments
Fidelity Investments
Massachusetts
-$46.6M
4
Voloridge Investment Management
Voloridge Investment Management
Florida
-$32.6M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
-$29.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
O
51
OrbiMed
New York
$25.7M +$2.61M +24,648 +11%
HRCM
52
Hood River Capital Management
Florida
$25.4M +$128K +1,207 +0.5%
Bank of America
53
Bank of America
North Carolina
$24M -$919K -8,666 -4%
LGM
54
Logos Global Management
California
$20.3M -$1.06M -10,000 -5%
Millennium Management
55
Millennium Management
New York
$20M +$5.68M +53,548 +40%
BNP Paribas Financial Markets
56
BNP Paribas Financial Markets
France
$17.6M -$6.27M -59,118 -26%
Citadel Advisors
57
Citadel Advisors
Florida
$16.4M +$2.2M +20,696 +16%
Connor, Clark & Lunn Investment Management (CC&L)
58
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$16M +$2.98M +28,113 +23%
FTM
59
First Turn Management
California
$15.7M +$15.5M +146,303 New
MGP
60
M&G plc
United Kingdom
$14.7M +$14.5M +137,074 New
SCM
61
Silverarc Capital Management
Massachusetts
$14.6M -$24.8M -234,046 -63%
Russell Investments Group
62
Russell Investments Group
United Kingdom
$14.4M -$2.49M -23,498 -15%
Barclays
63
Barclays
United Kingdom
$14.1M -$1.16M -10,949 -8%
Deutsche Bank
64
Deutsche Bank
Germany
$13.8M +$1.31M +12,381 +11%
Universal-Beteiligungs- und Servicegesellschaft
65
Universal-Beteiligungs- und Servicegesellschaft
Germany
$13.2M +$2.35M +22,165 +22%
N
66
Nuveen
North Carolina
$12.4M -$215K -2,030 -2%
Capital World Investors
67
Capital World Investors
California
$12.4M +$12.3M +115,693 New
Swiss National Bank
68
Swiss National Bank
Switzerland
$11.9M +$955K +9,000 +9%
New York State Common Retirement Fund
69
New York State Common Retirement Fund
New York
$10M +$1.97M +18,546 +25%
First Trust Advisors
70
First Trust Advisors
Illinois
$9.47M +$806K +7,602 +9%
AG
71
Algert Global
California
$9.45M -$5.52M -52,034 -37%
AI
72
Axiom Investors
Connecticut
$8.94M +$55.5K +523 +0.6%
ZDA
73
Zweig-DiMenna Associates
New York
$8.73M +$8.66M +81,600 New
SC
74
SummitTX Capital
Texas
$8.64M +$7.3M +68,860 +580%
ECM
75
ExodusPoint Capital Management
New York
$8.04M +$7.97M +75,141 New
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3
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RYTM Hedge Fund Activity: Q4 2025 in Review

279 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Rhythm Pharmaceuticals (RYTM) for Q4 2025, worth a combined $7.8B — up 8.3% from $7.2B a quarter earlier.

Buyers outnumbered sellers: 57 funds opened new RYTM positions and 40 closed out — a net gain of 17 holders — while 106 added to existing stakes and 89 trimmed.

The largest buyer was Vanguard Group, adding an estimated $129M. The largest seller was Alkeon Capital Management, exiting entirely with an estimated $103M sold.

  • 279 institutional investors held Rhythm Pharmaceuticals (RYTM) as of Q4 2025, up from 264 in Q3 2025.
  • Funds reported $7.8B of Rhythm Pharmaceuticals stock for Q4 2025, up 8.3% quarter-over-quarter.
  • 57 funds opened new Rhythm Pharmaceuticals positions in Q4 2025 and 40 closed out, a net change of +17 holders.
  • The largest Rhythm Pharmaceuticals buyer in Q4 2025 was Vanguard Group, an estimated $129M added.
  • The largest Rhythm Pharmaceuticals seller in Q4 2025 was Alkeon Capital Management, an estimated $103M sold.

Based on aggregated 13F filings for Q4 2025.