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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$119M
2
CC
Commodore Capital
New York
+$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$41.4M
4
BI
BVF Inc
California
+$35.2M
5
Holocene Advisors
Holocene Advisors
New York
+$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$21.3M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
-$21M
3
NVCHI
New Vernon Capital Holdings II
New Jersey
-$18.8M
4
AGP
Artia Global Partners
Florida
-$17.2M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$15.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
Citigroup
76
Citigroup
New York
$4.31M -$2.43M -43,893 -36%
Prudential Financial
77
Prudential Financial
New Jersey
$4.28M +$1.05M +19,050 +33%
SSA
78
Schonfeld Strategic Advisors
New York
$4.26M -$11.6M -210,233 -73%
DP
79
Diadema Partners
New Jersey
$4.21M +$4.21M +76,185 New
Royal Bank of Canada
80
Royal Bank of Canada
Ontario, Canada
$4.13M +$3.58M +64,770 +650%
EI
81
EAM Investors
California
$3.98M +$154K +2,790 +4%
Susquehanna International Group
82
Susquehanna International Group
Pennsylvania
$3.94M -$6.69M -120,998 -63%
EGI
83
EAM Global Investors
California
$3.85M -$1.33K -24 -0%
Qube Research & Technologies (QRT)
84
Qube Research & Technologies (QRT)
United Kingdom
$3.81M -$15.2M -274,428 -80%
AllianceBernstein
85
AllianceBernstein
Tennessee
$3.75M – – –
PHP
86
Parkman Healthcare Partners
Connecticut
$3.4M +$3.4M +61,596 New
BCM
87
Boxer Capital Management
California
$3.32M +$3.32M +60,000 New
HS
88
HighVista Strategies
Massachusetts
$3.2M -$1.14M -20,601 -26%
New York State Teachers Retirement System (NYSTRS)
89
New York State Teachers Retirement System (NYSTRS)
New York
$3.08M +$490K +8,858 +19%
SAM
90
Silvercrest Asset Management
New York
$3.02M – – –
AI
91
Axiom Investors
Connecticut
$2.83M +$623K +11,264 +28%
California State Teachers Retirement System (CalSTRS)
92
California State Teachers Retirement System (CalSTRS)
California
$2.83M +$516K +9,339 +22%
Canada Life
93
Canada Life
Manitoba, Canada
$2.78M -$39.4K -713 -1%
Capital Fund Management (CFM)
94
Capital Fund Management (CFM)
France
$2.75M +$2.75M +49,805 New
BC
95
Birchview Capital
Vermont
$2.65M -$111 -2 -0%
ETC
96
Exchange Traded Concepts
Oklahoma
$2.62M +$1.11M +19,999 +73%
Thrivent Financial for Lutherans
97
Thrivent Financial for Lutherans
Minnesota
$2.52M +$99.5K +1,800 +4%
SEI Investments
98
SEI Investments
Pennsylvania
$2.48M +$409K +7,404 +20%
N
99
Natixis
France
$2.32M +$2.32M +42,040 New
ACM
100
Aquatic Capital Management
Illinois
$2.32M +$1.49M +26,893 +178%
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4
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