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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$119M
2
CC
Commodore Capital
New York
+$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$41.4M
4
BI
BVF Inc
California
+$35.2M
5
Holocene Advisors
Holocene Advisors
New York
+$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$21.3M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
-$21M
3
NVCHI
New Vernon Capital Holdings II
New Jersey
-$18.8M
4
AGP
Artia Global Partners
Florida
-$17.2M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$15.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
Ameriprise
51
Ameriprise
Minnesota
$9.31M +$1.74M +31,529 +23%
Legal & General Group
52
Legal & General Group
United Kingdom
$9.18M +$999K +18,074 +12%
PAM
53
Panagora Asset Management
Massachusetts
$8.22M -$61.8K -1,118 -0.7%
GLA
54
Great Lakes Advisors
Illinois
$7.7M -$714K -12,927 -8%
NFT
55
Nan Fung Trinity
Hong Kong
$7.46M +$7.46M +135,050 New
KCM
56
Kennedy Capital Management
Missouri
$7.46M -$144K -2,614 -2%
NL
57
Nuveen LLC
North Carolina
$7.16M -$1.29M -23,260 -15%
SBH
58
Segall Bryant & Hamill
Illinois
$6.64M +$6.64M +120,159 New
TD Asset Management
59
TD Asset Management
Ontario, Canada
$6.43M -$2.96M -53,600 -32%
CLGM
60
Capitolis Liquid Global Markets
New York
$6.42M +$6.42M +116,100 New
First Trust Advisors
61
First Trust Advisors
Illinois
$6.3M +$1.78M +32,221 +39%
Deutsche Bank
62
Deutsche Bank
Germany
$6.14M +$2.51M +45,469 +69%
OM
63
Opaleye Management
Massachusetts
$5.8M – – –
Manulife (Manufacturers Life Insurance)
64
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$5.24M -$1.44M -26,049 -22%
Swiss National Bank
65
Swiss National Bank
Switzerland
$5.18M +$381K +6,900 +8%
Neuberger Berman Group
66
Neuberger Berman Group
New York
$5.17M +$5.17M +93,582 New
Assenagon Asset Management
67
Assenagon Asset Management
Luxembourg
$5.08M +$2.6M +47,003 +105%
Victory Capital Management
68
Victory Capital Management
Texas
$5.03M -$634K -11,479 -11%
Skandinaviska Enskilda Banken (SEB)
69
Skandinaviska Enskilda Banken (SEB)
Sweden
$4.57M -$9.19M -166,200 -67%
Franklin Resources
70
Franklin Resources
California
$4.56M +$195K +3,535 +4%
EAM
71
EFG Asset Management
Oregon
$4.52M +$586K +10,592 +15%
CC
72
Checkpoint Capital
California
$4.49M -$5.19M -93,873 -54%
Rafferty Asset Management
73
Rafferty Asset Management
New York
$4.45M +$2.01M +36,286 +82%
DMKJ
74
David M. Knott Jr
$4.42M +$221K +4,000 +5%
Northwestern Mutual Wealth Management
75
Northwestern Mutual Wealth Management
Wisconsin
$4.36M – – –
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