|
1
|
Franklin Resources
San Mateo,
California
|
$21.9M
|
+$883K
|
+4,937
|
+4%
|
|
|
2
|
New Leaf Venture Partners
New York
|
$21.5M
|
–
|
–
|
–
|
|
|
3
|
VHCP Management II
New York
|
$17.7M
|
–
|
–
|
–
|
|
|
4
|
Fidelity Investments
Boston,
Massachusetts
|
$10.4M
|
-$15.8M
|
-88,446
|
-61%
|
|
|
5
|
Eagle Asset Management
St Petersburg,
Florida
|
$7.97M
|
-$63.3K
|
-354
|
-0.8%
|
|
|
6
|
Janus Henderson Investors US
Denver,
Colorado
|
$6.55M
|
+$64.7K
|
+362
|
+1%
|
|
|
7
|
Acuta Capital Partners
Redwood City,
California
|
$3.52M
|
+$2.02M
|
+11,315
|
+143%
|
|
|
8
|
Asset Management One
Tokyo,
Japan
|
$2.47M
|
+$715
|
+4
|
+0%
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$1.98M
|
+$547K
|
+3,059
|
+39%
|
|
|
10
|
BlackRock Fund Advisors
San Francisco,
California
|
$1.97M
|
-$106K
|
-594
|
-5%
|
|
|
11
|
Millennium Management
New York
|
$1.82M
|
+$158K
|
+882
|
+10%
|
|
|
12
|
Opaleye Management
Boston,
Massachusetts
|
$1.69M
|
+$1.65M
|
+9,250
|
New
|
|
|
13
|
Sphera Funds Management
Tel Aviv,
Israel
|
$1.37M
|
-$44.7K
|
-250
|
-3%
|
|
|
14
|
|
$1.24M
|
–
|
–
|
–
|
|
|
15
|
|
$1.11M
|
+$52.6K
|
+294
|
+5%
|
|
|
16
|
State Street
Boston,
Massachusetts
|
$897K
|
+$274K
|
+1,535
|
+46%
|
|
|
17
|
Northern Trust
Chicago,
Illinois
|
$745K
|
–
|
–
|
–
|
|
|
18
|
BlackRock Institutional Trust
San Francisco,
California
|
$682K
|
+$334K
|
+1,869
|
+101%
|
|
|
19
|
DAFNA Capital Management
Los Angeles,
California
|
$633K
|
+$618K
|
+3,459
|
New
|
|
|
20
|
Geode Capital Management
Boston,
Massachusetts
|
$610K
|
+$52.2K
|
+292
|
+10%
|
|
|
21
|
Raymond James Financial Services Advisors
St. Petersburg,
Florida
|
$421K
|
+$411K
|
+2,300
|
New
|
|
|
22
|
BlackRock Investment Management
Wilmington,
Delaware
|
$280K
|
+$12K
|
+67
|
+5%
|
|
|
23
|
Charles Schwab
San Francisco,
California
|
$242K
|
+$4.11K
|
+23
|
+2%
|
|
|
24
|
Bank of New York Mellon
New York
|
$204K
|
+$27.7K
|
+155
|
+16%
|
|
|
25
|
|
$175K
|
+$139K
|
+777
|
+427%
|
|
