Puma Biotechnology
PBYI
132 hedge funds and large institutions have $183M invested in Puma Biotechnology in 2025 Q3 according to their latest regulatory filings, with 23 funds opening new positions, 43 increasing their positions, 36 reducing their positions, and 12 closing their positions.
172,500% more call options, than puts
Call options by funds: $1.73M | Put options by funds: $1K
92% more first-time investments, than exits
New positions opened: 23 | Existing positions closed: 12
62% more capital invested
Capital invested by funds: $113M → $183M (+$70M)
19% more repeat investments, than reductions
Existing positions increased: 43 | Existing positions reduced: 36
9% more funds holding
Funds holding: 121 → 132 (+11)
2.14% more ownership
Funds ownership: 66.11% → 68.26% (+2.1%)
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Russell Investments Group
London,
United Kingdom
|
+$4.09M |
| 2 |
Marshall Wace
London,
United Kingdom
|
+$2.05M |
| 3 |
OSAM
O'Shaughnessy Asset Management
Stamford,
Connecticut
|
+$1.66M |
| 4 |
Renaissance Technologies
New York
|
+$1.17M |
| 5 |
RWM
Ritholtz Wealth Management
New York
|
+$1.16M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Janus Henderson Group
London,
United Kingdom
|
-$2.56M |
| 2 |
Citadel Advisors
Miami,
Florida
|
-$2.15M |
| 3 |
BlackRock
New York
|
-$1.09M |
| 4 |
Millennium Management
New York
|
-$971K |
| 5 |
EP
Eversept Partners
New York
|
-$826K |
PBYI Hedge Fund Activity: Q3 2025 in Review
132 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Puma Biotechnology (PBYI) for Q3 2025, worth a combined $183M — up 62% from $113M a quarter earlier.
Buyers outnumbered sellers: 23 funds opened new PBYI positions and 12 closed out — a net gain of 11 holders — while 43 added to existing stakes and 36 trimmed.
The largest buyer was Russell Investments Group, adding an estimated $4.09M. The largest seller was Janus Henderson Group, exiting entirely with an estimated $2.56M sold.
- 132 institutional investors held Puma Biotechnology (PBYI) as of Q3 2025, up from 121 in Q2 2025.
- Funds reported $183M of Puma Biotechnology stock for Q3 2025, up 62% quarter-over-quarter.
- 23 funds opened new Puma Biotechnology positions in Q3 2025 and 12 closed out, a net change of +11 holders.
- The largest Puma Biotechnology buyer in Q3 2025 was Russell Investments Group, an estimated $4.09M added.
- The largest Puma Biotechnology seller in Q3 2025 was Janus Henderson Group, an estimated $2.56M sold.
Based on aggregated 13F filings for Q3 2025.