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Puma Biotechnology
PBYI

121 hedge funds and large institutions have $113M invested in Puma Biotechnology in 2025 Q2 according to their latest regulatory filings, with 22 funds opening new positions, 42 increasing their positions, 32 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

8,150% more call options, than puts

Call options by funds: $330K | Put options by funds: $4K

38% more first-time investments, than exits

New positions opened: 22 | Existing positions closed: 16

31% more repeat investments, than reductions

Existing positions increased: 42 | Existing positions reduced: 32

25% more capital invested

Capital invested by funds: $90M → $113M (+$22.5M)

4.81% more ownership

Funds ownership: 61.31% → 66.11% (+4.8%)

4% more funds holding

Funds holding: 116 → 121 (+5)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

Holders
121
Holders Change
+5
Holders Change %
+4.31%
% of All Funds
1.59%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
22
Increased
42
Reduced
32
Closed
16
Calls
$330K
Puts
$4K
Net Calls
+$326K
Net Calls Change
+$158K

Top Buyers

Rank Fund Capital Flow
1
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$2.38M
2
Citadel Advisors
Citadel Advisors
Florida
+$1.62M
3
LSV Asset Management
LSV Asset Management
Illinois
+$1.54M
4
OSAM
O'Shaughnessy Asset Management
Connecticut
+$1.05M
5
Dimensional Fund Advisors
Dimensional Fund Advisors
Texas
+$834K

Top Sellers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
-$3.35M
2
Marshall Wace
Marshall Wace
United Kingdom
-$456K
3
Goldman Sachs
Goldman Sachs
New York
-$294K
4
GCP
GSA Capital Partners
United Kingdom
-$294K
5
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$228K
Name Holding Trade Value Shares
Change 		Change in
Stake
ACA
1
Acorn Capital Advisors
New York
$14.2M +$610K +191,247 +5%
BlackRock
2
BlackRock
New York
$13.2M -$37.2K -11,653 -0.3%
Vanguard Group
3
Vanguard Group
Pennsylvania
$12.7M +$119K +37,189 +1%
Acadian Asset Management
4
Acadian Asset Management
Massachusetts
$6.88M – – –
Renaissance Technologies
5
Renaissance Technologies
New York
$6.43M +$145K +45,500 +2%
American Century Companies
6
American Century Companies
Missouri
$4.6M +$615K +192,615 +17%
Dimensional Fund Advisors
7
Dimensional Fund Advisors
Texas
$3.94M +$834K +261,377 +29%
KCM
8
Kennedy Capital Management
Missouri
$3.39M +$242K +75,878 +8%
Geode Capital Management
9
Geode Capital Management
Massachusetts
$3.33M +$51.8K +16,218 +2%
Connor, Clark & Lunn Investment Management (CC&L)
10
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$3.09M +$219K +68,567 +8%
Janus Henderson Group
11
Janus Henderson Group
United Kingdom
$2.56M +$2.38M +745,541 New
State Street
12
State Street
Massachusetts
$2.52M +$271K +84,814 +13%
D.E. Shaw & Co
13
D.E. Shaw & Co
New York
$2.2M +$221K +69,115 +12%
LSV Asset Management
14
LSV Asset Management
Illinois
$1.84M +$1.54M +482,340 +903%
Citadel Advisors
15
Citadel Advisors
Florida
$1.74M +$1.62M +507,818 New
GC
16
Globeflex Capital
California
$1.55M – – –
Arrowstreet Capital
17
Arrowstreet Capital
Massachusetts
$1.55M +$297K +93,012 +26%
Los Angeles Capital Management
18
Los Angeles Capital Management
California
$1.53M +$123K +38,623 +9%
OSAM
19
O'Shaughnessy Asset Management
Connecticut
$1.5M +$1.05M +329,715 +305%
SEI Investments
20
SEI Investments
Pennsylvania
$1.19M -$1.42K -445 -0.1%
Bank of New York Mellon
21
Bank of New York Mellon
New York
$1.18M +$10.2K +3,197 +0.9%
Millennium Management
22
Millennium Management
New York
$1.15M -$3.35M -1,050,585 -76%
Morgan Stanley
23
Morgan Stanley
New York
$1.11M +$191K +59,924 +23%
Northern Trust
24
Northern Trust
Illinois
$1.04M -$49.2K -15,423 -5%
Prudential Financial
25
Prudential Financial
New Jersey
$965K -$85.9K -26,911 -9%
1
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PBYI Hedge Fund Activity: Q2 2025 in Review

121 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Puma Biotechnology (PBYI) for Q2 2025, worth a combined $113M — up 25% from $90M a quarter earlier.

Buyers outnumbered sellers: 22 funds opened new PBYI positions and 16 closed out — a net gain of 6 holders — while 42 added to existing stakes and 32 trimmed.

The largest buyer was Janus Henderson Group, opening a new position worth an estimated $2.38M. The largest seller was Millennium Management, cutting an estimated $3.35M.

  • 121 institutional investors held Puma Biotechnology (PBYI) as of Q2 2025, up from 116 in Q1 2025.
  • Funds reported $113M of Puma Biotechnology stock for Q2 2025, up 25% quarter-over-quarter.
  • 22 funds opened new Puma Biotechnology positions in Q2 2025 and 16 closed out, a net change of +6 holders.
  • The largest Puma Biotechnology buyer in Q2 2025 was Janus Henderson Group, an estimated $2.38M added.
  • The largest Puma Biotechnology seller in Q2 2025 was Millennium Management, an estimated $3.35M sold.

Based on aggregated 13F filings for Q2 2025.