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Omeros
OMER

133 hedge funds and large institutions have $135M invested in Omeros in 2025 Q3 according to their latest regulatory filings, with 15 funds opening new positions, 58 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

93% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 30

67% more first-time investments, than exits

New positions opened: 15 | Existing positions closed: 9

54% more capital invested

Capital invested by funds: $87.3M → $135M (+$47.4M)

5% more funds holding

Funds holding: 127 → 133 (+6)

5% less call options, than puts

Call options by funds: $10.4M | Put options by funds: $10.9M

1.41% less ownership

Funds ownership: 49.68% → 48.27% (-1.4%)

Holders
133
Holders Change
+6
Holders Change %
+4.72%
% of All Funds
1.75%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
15
Increased
58
Reduced
30
Closed
9
Calls
$10.4M
Puts
$10.9M
Net Calls
-$517K
Net Calls Change
+$1.24M

Top Buyers

Rank Fund Capital Flow
1
PAMP
Polar Asset Management Partners
Ontario, Canada
+$5.95M
2
Morgan Stanley
Morgan Stanley
New York
+$2.52M
3
BlackRock
BlackRock
New York
+$1.59M
4
JP Morgan Chase
JP Morgan Chase
New York
+$1.52M
5
Stifel Financial
Stifel Financial
Missouri
+$1.15M

Top Sellers

Rank Fund Capital Flow
1
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$2.55M
2
DIG
DeepCurrents Investment Group
New York
-$1.62M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.1M
4
UBS Group
UBS Group
Switzerland
-$632K
5
GCM
Graham Capital Management
Connecticut
-$262K
Name Holding Trade Value Shares
Change 		Change in
Stake
EWA
126
EverSource Wealth Advisors
Alabama
$472 -$270 -68 -37%
AF
127
Allworth Financial
California
$234 +$226 +57 New
US Bancorp
128
US Bancorp
Minnesota
$205 -$198 -50 -50%
SA
129
SRH Advisors
Kansas
$205 – – –
CA
130
Clearstead Advisors
Ohio
$107 +$103 +26 New
IA
131
IFP Advisors
Florida
$107 +$103 +26 New
EP
132
Essential Partners
California
$45 +$44 +11 New
A
133
AlphaQuest
New York
$4 – – –
XT
134
XTX Topco
Cayman Islands
– -$191K -63,777 Closed
CC
135
Corton Capital
Ontario, Canada
– -$117K -38,967 Closed
SA
136
Sanctuary Advisors
Indiana
– -$107K -35,515 Closed
State Board of Administration of Florida Retirement System
137
State Board of Administration of Florida Retirement System
Florida
– -$52.3K -17,430 Closed
HSBC Holdings
138
HSBC Holdings
United Kingdom
– -$34.8K -11,181 Closed
Raymond James Financial
139
Raymond James Financial
Florida
– -$29.3K -9,781 Closed
CIAS
140
CBIZ Investment Advisory Services
Ohio
– -$900 -300 Closed
CIAM
141
Caitong International Asset Management
Hong Kong
– -$312 -104 Closed
AAS
142
Ameritas Advisory Services
Nebraska
– -$93 -31 Closed
2 3 4 5
6

OMER Hedge Fund Activity: Q3 2025 in Review

133 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q3 2025, worth a combined $135M — up 54% from $87.3M a quarter earlier.

Buyers outnumbered sellers: 15 funds opened new OMER positions and 9 closed out — a net gain of 6 holders — while 58 added to existing stakes and 30 trimmed.

The largest buyer was Polar Asset Management Partners, opening a new position worth an estimated $5.95M. The largest seller was D.E. Shaw & Co, cutting an estimated $2.55M.

  • 133 institutional investors held Omeros (OMER) as of Q3 2025, up from 127 in Q2 2025.
  • Funds reported $135M of Omeros stock for Q3 2025, up 54% quarter-over-quarter.
  • 15 funds opened new Omeros positions in Q3 2025 and 9 closed out, a net change of +6 holders.
  • The largest Omeros buyer in Q3 2025 was Polar Asset Management Partners, an estimated $5.95M added.
  • The largest Omeros seller in Q3 2025 was D.E. Shaw & Co, an estimated $2.55M sold.

Based on aggregated 13F filings for Q3 2025.