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Omeros
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133 hedge funds and large institutions have $135M invested in Omeros in 2025 Q3 according to their latest regulatory filings, with 15 funds opening new positions, 58 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

93% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 30

67% more first-time investments, than exits

New positions opened: 15 | Existing positions closed: 9

54% more capital invested

Capital invested by funds: $87.3M → $135M (+$47.4M)

5% more funds holding

Funds holding: 127 → 133 (+6)

5% less call options, than puts

Call options by funds: $10.4M | Put options by funds: $10.9M

1.41% less ownership

Funds ownership: 49.68% → 48.27% (-1.4%)

Holders
133
Holders Change
+6
Holders Change %
+4.72%
% of All Funds
1.75%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
15
Increased
58
Reduced
30
Closed
9
Calls
$10.4M
Puts
$10.9M
Net Calls
-$517K
Net Calls Change
+$1.24M

Top Buyers

Rank Fund Capital Flow
1
PAMP
Polar Asset Management Partners
Ontario, Canada
+$5.95M
2
Morgan Stanley
Morgan Stanley
New York
+$2.52M
3
BlackRock
BlackRock
New York
+$1.59M
4
JP Morgan Chase
JP Morgan Chase
New York
+$1.52M
5
Stifel Financial
Stifel Financial
Missouri
+$1.15M

Top Sellers

Rank Fund Capital Flow
1
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$2.55M
2
DIG
DeepCurrents Investment Group
New York
-$1.62M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.1M
4
UBS Group
UBS Group
Switzerland
-$632K
5
GCM
Graham Capital Management
Connecticut
-$262K
Name Holding Trade Value Shares
Change 		Change in
Stake
AAP
101
Arax Advisory Partners
Colorado
$13.8K +$13.3K +3,361 New
PA
102
Parallel Advisors
California
$13K +$4.6K +1,159 +58%
AA
103
Ancora Advisors
Ohio
$12.3K -$11.1K -2,800 -48%
Mirae Asset Global Investments
104
Mirae Asset Global Investments
South Korea
$10.8K +$1.46K +368 +16%
AB
105
Amalgamated Bank
New York
$8K – – –
SIS
106
Strategic Investment Solutions
Illinois
$7.48K – – –
TC
107
Truvestments Capital
Florida
$6.9K -$5.63K -1,420 -46%
Nisa Investment Advisors
108
Nisa Investment Advisors
Missouri
$6.86K +$345 +87 +5%
GFM
109
GF Fund Management
China
$6K -$75 -19 -1%
MCM
110
MAI Capital Management
Ohio
$5.61K – – –
Carson Wealth (CWM LLC)
111
Carson Wealth (CWM LLC)
Nebraska
$5K +$2.58K +651 +107%
Zurich Cantonal Bank
112
Zurich Cantonal Bank
Switzerland
$4.1K -$1.42K -358 -26%
Fifth Third Bancorp
113
Fifth Third Bancorp
Ohio
$4.1K – – –
PMFA
114
Plante Moran Financial Advisors
Michigan
$4.1K +$3.97K +1,000 New
CAL
115
Capital Analysts LLC
Pennsylvania
$4K – – –
PNC Financial Services Group
116
PNC Financial Services Group
Pennsylvania
$2.76K +$83 +21 +3%
SCM
117
Sterling Capital Management
North Carolina
$2.65K +$1.4K +352 +120%
Optiver Holding
118
Optiver Holding
Netherlands
$2.21K +$2.13K +538 New
Northwestern Mutual Wealth Management
119
Northwestern Mutual Wealth Management
Wisconsin
$2.05K +$1.98K +500 New
PW
120
Pandora Wealth
Illinois
$1.35K – – –
FDCDDQ
121
Federation des caisses Desjardins du Quebec
Quebec, Canada
$1.23K – – –
Daiwa Securities Group
122
Daiwa Securities Group
Japan
$1K – – –
SS
123
SBI Securities
Japan
$853 – – –
LFG
124
Larson Financial Group
Missouri
$615 – – –
MPWT
125
MassMutual Private Wealth & Trust
Connecticut
$508 +$492 +124 New
2 3 4
5
6

OMER Hedge Fund Activity: Q3 2025 in Review

133 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q3 2025, worth a combined $135M — up 54% from $87.3M a quarter earlier.

Buyers outnumbered sellers: 15 funds opened new OMER positions and 9 closed out — a net gain of 6 holders — while 58 added to existing stakes and 30 trimmed.

The largest buyer was Polar Asset Management Partners, opening a new position worth an estimated $5.95M. The largest seller was D.E. Shaw & Co, cutting an estimated $2.55M.

  • 133 institutional investors held Omeros (OMER) as of Q3 2025, up from 127 in Q2 2025.
  • Funds reported $135M of Omeros stock for Q3 2025, up 54% quarter-over-quarter.
  • 15 funds opened new Omeros positions in Q3 2025 and 9 closed out, a net change of +6 holders.
  • The largest Omeros buyer in Q3 2025 was Polar Asset Management Partners, an estimated $5.95M added.
  • The largest Omeros seller in Q3 2025 was D.E. Shaw & Co, an estimated $2.55M sold.

Based on aggregated 13F filings for Q3 2025.