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Omeros
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133 hedge funds and large institutions have $135M invested in Omeros in 2025 Q3 according to their latest regulatory filings, with 15 funds opening new positions, 58 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

93% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 30

67% more first-time investments, than exits

New positions opened: 15 | Existing positions closed: 9

54% more capital invested

Capital invested by funds: $87.3M → $135M (+$47.4M)

5% more funds holding

Funds holding: 127 → 133 (+6)

5% less call options, than puts

Call options by funds: $10.4M | Put options by funds: $10.9M

1.41% less ownership

Funds ownership: 49.68% → 48.27% (-1.4%)

Holders
133
Holders Change
+6
Holders Change %
+4.72%
% of All Funds
1.75%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
15
Increased
58
Reduced
30
Closed
9
Calls
$10.4M
Puts
$10.9M
Net Calls
-$517K
Net Calls Change
+$1.24M

Top Buyers

Rank Fund Capital Flow
1
PAMP
Polar Asset Management Partners
Ontario, Canada
+$5.95M
2
Morgan Stanley
Morgan Stanley
New York
+$2.52M
3
BlackRock
BlackRock
New York
+$1.59M
4
JP Morgan Chase
JP Morgan Chase
New York
+$1.52M
5
Stifel Financial
Stifel Financial
Missouri
+$1.15M

Top Sellers

Rank Fund Capital Flow
1
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$2.55M
2
DIG
DeepCurrents Investment Group
New York
-$1.62M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.1M
4
UBS Group
UBS Group
Switzerland
-$632K
5
GCM
Graham Capital Management
Connecticut
-$262K
Name Holding Trade Value Shares
Change 		Change in
Stake
QCM
76
Quantinno Capital Management
New York
$74.7K +$72.2K +18,208 New
SFI
77
SPC Financial Inc
Maryland
$71.3K – – –
BIM
78
Breakwater Investment Management
Washington
$69.9K – – –
PFSRSONJ
79
Police & Firemen's Retirement System of New Jersey
New Jersey
$67.1K +$18.4K +4,638 +40%
Walleye Capital
80
Walleye Capital
New York
$61.2K +$50.1K +12,638 +553%
Walleye Trading
81
Walleye Trading
New York
$56.1K +$54.3K +13,673 New
ProShare Advisors
82
ProShare Advisors
Maryland
$55.5K -$897 -226 -2%
HI
83
Harbour Investments
Wisconsin
$55.2K – – –
Fidelity Investments
84
Fidelity Investments
Massachusetts
$54.1K +$6.15K +1,550 +13%
SEI Investments
85
SEI Investments
Pennsylvania
$53.8K -$1.2K -302 -2%
New York State Common Retirement Fund
86
New York State Common Retirement Fund
New York
$46.8K – – –
IAIM
87
International Assets Investment Management
Florida
$46.2K – – –
VOYA Investment Management
88
VOYA Investment Management
Georgia
$45.9K -$18.8K -4,727 -30%
BRWA
89
B. Riley Wealth Advisors
Florida
$44.1K – – –
Russell Investments Group
90
Russell Investments Group
United Kingdom
$43.8K +$22.5K +5,677 +113%
SFS
91
Sowell Financial Services
Arkansas
$42.8K -$1.19K -300 -3%
APP
92
Avantax Planning Partners
Iowa
$41.4K – – –
GCP
93
GSA Capital Partners
United Kingdom
$41K -$112K -28,128 -74%
Legal & General Group
94
Legal & General Group
United Kingdom
$29K +$3.91K +985 +16%
FFA
95
Farther Finance Advisors
California
$25K -$5.54K -1,395 -19%
Osaic Holdings
96
Osaic Holdings
Arizona
$23.3K +$1.1K +277 +5%
Citigroup
97
Citigroup
New York
$22.6K -$68.1K -17,172 -76%
AIP
98
Ameritas Investment Partners
Nebraska
$20.6K – – –
California State Teachers Retirement System (CalSTRS)
99
California State Teachers Retirement System (CalSTRS)
California
$16.6K +$12 +3 +0.1%
TRCT
100
Tower Research Capital (TRC)
New York
$14.1K -$39.6K -9,986 -74%
2 3
4
5 6

OMER Hedge Fund Activity: Q3 2025 in Review

133 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q3 2025, worth a combined $135M — up 54% from $87.3M a quarter earlier.

Buyers outnumbered sellers: 15 funds opened new OMER positions and 9 closed out — a net gain of 6 holders — while 58 added to existing stakes and 30 trimmed.

The largest buyer was Polar Asset Management Partners, opening a new position worth an estimated $5.95M. The largest seller was D.E. Shaw & Co, cutting an estimated $2.55M.

  • 133 institutional investors held Omeros (OMER) as of Q3 2025, up from 127 in Q2 2025.
  • Funds reported $135M of Omeros stock for Q3 2025, up 54% quarter-over-quarter.
  • 15 funds opened new Omeros positions in Q3 2025 and 9 closed out, a net change of +6 holders.
  • The largest Omeros buyer in Q3 2025 was Polar Asset Management Partners, an estimated $5.95M added.
  • The largest Omeros seller in Q3 2025 was D.E. Shaw & Co, an estimated $2.55M sold.

Based on aggregated 13F filings for Q3 2025.