Omeros
OMER
133 hedge funds and large institutions have $135M invested in Omeros in 2025 Q3 according to their latest regulatory filings, with 15 funds opening new positions, 58 increasing their positions, 30 reducing their positions, and 9 closing their positions.
93% more repeat investments, than reductions
Existing positions increased: 58 | Existing positions reduced: 30
67% more first-time investments, than exits
New positions opened: 15 | Existing positions closed: 9
54% more capital invested
Capital invested by funds: $87.3M → $135M (+$47.4M)
5% more funds holding
Funds holding: 127 → 133 (+6)
5% less call options, than puts
Call options by funds: $10.4M | Put options by funds: $10.9M
1.41% less ownership
Funds ownership: 49.68% → 48.27% (-1.4%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
PAMP
Polar Asset Management Partners
Toronto,
Ontario, Canada
|
+$5.95M |
| 2 |
Morgan Stanley
New York
|
+$2.52M |
| 3 |
BlackRock
New York
|
+$1.59M |
| 4 |
JP Morgan Chase
New York
|
+$1.52M |
| 5 |
Stifel Financial
St. Louis,
Missouri
|
+$1.15M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
D.E. Shaw & Co
New York
|
-$2.55M |
| 2 |
DIG
DeepCurrents Investment Group
New York
|
-$1.62M |
| 3 |
Marshall Wace
London,
United Kingdom
|
-$1.1M |
| 4 |
UBS Group
Zurich,
Switzerland
|
-$632K |
| 5 |
GCM
Graham Capital Management
Rowayton,
Connecticut
|
-$262K |
OMER Hedge Fund Activity: Q3 2025 in Review
133 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q3 2025, worth a combined $135M — up 54% from $87.3M a quarter earlier.
Buyers outnumbered sellers: 15 funds opened new OMER positions and 9 closed out — a net gain of 6 holders — while 58 added to existing stakes and 30 trimmed.
The largest buyer was Polar Asset Management Partners, opening a new position worth an estimated $5.95M. The largest seller was D.E. Shaw & Co, cutting an estimated $2.55M.
- 133 institutional investors held Omeros (OMER) as of Q3 2025, up from 127 in Q2 2025.
- Funds reported $135M of Omeros stock for Q3 2025, up 54% quarter-over-quarter.
- 15 funds opened new Omeros positions in Q3 2025 and 9 closed out, a net change of +6 holders.
- The largest Omeros buyer in Q3 2025 was Polar Asset Management Partners, an estimated $5.95M added.
- The largest Omeros seller in Q3 2025 was D.E. Shaw & Co, an estimated $2.55M sold.
Based on aggregated 13F filings for Q3 2025.