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MREO

Mereo BioPharma
MREO

90 hedge funds and large institutions have $250M invested in Mereo BioPharma in 2025 Q1 according to their latest regulatory filings, with 13 funds opening new positions, 27 increasing their positions, 21 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more call options, than puts

Call options by funds: $3.5M | Put options by funds: $1.75M

29% more repeat investments, than reductions

Existing positions increased: 27 | Existing positions reduced: 21

0.88% less ownership

Funds ownership: 14.85% → 13.97% (-0.88%)

7% less first-time investments, than exits

New positions opened: 13 | Existing positions closed: 14

1% less funds holding

Funds holding: 91 → 90 (-1)

38% less capital invested

Capital invested by funds: $403M → $250M (-$153M)

50% less funds holding in top 10

Funds holding in top 10: 2 → 1 (-1)

Holders
90
Holders Change
-1
Holders Change %
-1.1%
% of All Funds
1.21%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
13
Increased
27
Reduced
21
Closed
14
Calls
$3.5M
Puts
$1.75M
Net Calls
+$1.75M
Net Calls Change
+$564K

Top Buyers

Rank Fund Capital Flow
1
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$15.9M
2
FLSM
Frazier Life Sciences Management
California
+$7.7M
3
Aberdeen Group
Aberdeen Group
United Kingdom
+$6.19M
4
SSA
Schonfeld Strategic Advisors
New York
+$3.1M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$2.15M

Top Sellers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$19.8M
2
Millennium Management
Millennium Management
New York
-$10.1M
3
RSCM
Rock Springs Capital Management
Maryland
-$8.25M
4
UBS Group
UBS Group
Switzerland
-$4.85M
5
Morgan Stanley
Morgan Stanley
New York
-$3.89M
Name Holding Trade Value Shares
Change 		Change in
Stake
SCM
26
Soleus Capital Management
Connecticut
$1.55M -$283K -100,000 -13%
TE
27
Tema ETFs
New York
$1.47M -$667K -235,882 -26%
NIM
28
NEOS Investment Management
Connecticut
$1.47M -$481K -169,937 -21%
Hudson Bay Capital Management
29
Hudson Bay Capital Management
Connecticut
$1.01M +$382K +135,000 +43%
Bank of America
30
Bank of America
North Carolina
$987K +$1.23M +436,350 +18,808%
AGP
31
Artia Global Partners
Florida
$948K – – –
MAM
32
Monaco Asset Management
Monaco
$937K +$99K +35,000 +9%
Millennium Management
33
Millennium Management
New York
$887K -$10.1M -3,571,001 -90%
HP
34
HealthInvest Partners
Sweden
$878K – – –
CF
35
Cantor Fitzgerald
New York
$799K +$368K +130,000 +58%
Citadel Advisors
36
Citadel Advisors
Florida
$773K +$84K +29,703 +9%
DMKJ
37
David M. Knott Jr
$719K -$33K -11,663 -4%
BlackRock
38
BlackRock
New York
$617K +$3.8K +1,342 +0.5%
KCM
39
Knoll Capital Management
Florida
$586K – – –
Two Sigma Investments
40
Two Sigma Investments
New York
$552K +$499K +176,471 +257%
Susquehanna International Group
41
Susquehanna International Group
Pennsylvania
$392K -$614K -217,212 -55%
Jane Street
42
Jane Street
New York
$326K +$69.4K +24,525 +20%
PAP
43
Persistent Asset Partners
Hong Kong
$255K +$320K +113,247 New
CM
44
Caption Management
Oklahoma
$236K +$296K +104,783 New
BC
45
BIT Capital
Germany
$227K +$286K +101,070 New
Geode Capital Management
46
Geode Capital Management
Massachusetts
$207K – – –
JGC
47
J. Goldman & Co
New York
$179K – – –
DP
48
Diadema Partners
New Jersey
$169K +$1.39M +492,215 New
GCM
49
Graham Capital Management
Connecticut
$111K +$77K +27,229 +123%
FA
50
Forefront Analytics
Pennsylvania
$107K +$36.4K +12,877 +37%
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MREO Hedge Fund Activity: Q1 2025 in Review

90 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Mereo BioPharma (MREO) for Q1 2025, worth a combined $250M — down 38% from $403M a quarter earlier.

Sellers outnumbered buyers: 14 funds closed out of MREO and 13 opened new positions — a net loss of 1 holder — while 21 trimmed existing stakes and 27 added.

The largest buyer was Janus Henderson Group, adding an estimated $15.9M. The largest seller was Adage Capital Partners, cutting an estimated $19.8M.

  • 90 institutional investors held Mereo BioPharma (MREO) as of Q1 2025, down from 91 in Q4 2024.
  • Funds reported $250M of Mereo BioPharma stock for Q1 2025, down 38% quarter-over-quarter.
  • 13 funds opened new Mereo BioPharma positions in Q1 2025 and 14 closed out, a net change of -1 holder.
  • The largest Mereo BioPharma buyer in Q1 2025 was Janus Henderson Group, an estimated $15.9M added.
  • The largest Mereo BioPharma seller in Q1 2025 was Adage Capital Partners, an estimated $19.8M sold.

Based on aggregated 13F filings for Q1 2025.