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Madrigal Pharmaceuticals

MDGL

Market cap $12.2B

378 hedge funds and large institutions have $12.4B invested in Madrigal Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 62 funds opening new positions, 130 increasing their positions, 129 reducing their positions, and 63 closing their positions.

New

Increased

Maintained

Reduced

Closed

96% more call options, than puts

Call options by funds: $397M | Put options by funds: $203M

1% more repeat investments, than reductions

Existing positions increased: 130 | Existing positions reduced: 129

0.14% less ownership

Funds ownership: 103.78% → 103.63% (-0.14%)

2% less first-time investments, than exits

New positions opened: 62 | Existing positions closed: 63

2% less funds holding

Funds holding: 387 → 378 (-9)

9% less capital invested

Capital invested by funds: $13.7B → $12.4B (-$1.28B)

38% less funds holding in top 10

Funds holding in top 10: 13 → 8 (-5)

Holders

378

Holders Change

-9

Holders Change %

-2.33%

% of All Funds

4.66%

Holding in Top 10

Holding in Top 10 Change

-5

Holding in Top 10 Change %

-38.46%

% of All Funds

0.1%

New

Increased

130

Reduced

129

Closed

Calls

$397M

Puts

$203M

Net Calls

+$195M

Net Calls Change

+$142M

Top Buyers

1	Janus Henderson Group London, United Kingdom	+$207M
2	Citadel Advisors Miami, Florida	+$200M
3	Wellington Management Group Boston, Massachusetts	+$112M
4	Adage Capital Partners Boston, Massachusetts	+$77.4M
5	Toronto Dominion Bank Toronto, Ontario, Ontario, Canada	+$62.3M

Top Sellers

1	PC Paulson & Co New York	-$151M
2	Bank of America Charlotte, North Carolina	-$108M
3	Alkeon Capital Management New York	-$76.4M
4	MB MPM BioImpact Boston, Massachusetts	-$56.4M
5	Deutsche Bank Frankfurt Am Main Ge, Germany	-$44.9M

#	Name	Holding	Trade Value	Shares Change	Change in Stake
26	26 Pictet Asset Management Carouge, Switzerland	$97.9M	+$2.53M	+5,291	+3%
27	27 Adage Capital Partners Boston, Massachusetts	$97M	+$77.4M	+162,105	+698%
28	28 Artisan Partners Milwaukee, Wisconsin	$96.1M	-$7.24M	-15,153	-8%
29	29 Fiera Capital (Canada) Montreal, Quebec, Canada	$91.1M	+$2.18M	+4,555	+3%
30	RSCM 30 Rock Springs Capital Management Baltimore, Maryland	$89.5M	+$15M	+31,381	+22%
31	31 American Century Companies Kansas City, Missouri	$85.8M	-$10.1M	-21,183	-11%
32	EAM 32 Erste Asset Management Vienna, Austria	$81M	+$9.13M	+19,110	+14%
33	33 Northern Trust Chicago, Illinois	$78.1M	-$1.24M	-2,588	-2%
34	34 AllianceBernstein Nashville, Tennessee	$73.1M	+$49.5M	+103,535	+473%
35	35 Bank of New York Mellon New York	$71.1M	-$459K	-961	-0.7%
36	36 Toronto Dominion Bank Toronto, Ontario, Ontario, Canada	$68.3M	+$62.3M	+130,460	New
37	VFT 37 Vanguard Fiduciary Trust Malvern, Pennsylvania	$67M	+$61.2M	+128,079	New
38	WP 38 Woodline Partners San Francisco, California	$65.9M	+$115K	+240	+0.2%
39	39 UBS Group Zurich, Switzerland	$61.7M	+$7.23M	+15,138	+15%
40	DCM 40 Driehaus Capital Management Chicago, Illinois	$58.1M	-$337K	-706	-0.6%
41	TLP 41 Tri Locum Partners New York	$54.1M	+$8.25M	+17,265	+20%
42	42 Ameriprise Minneapolis, Minnesota	$51.4M	+$32.9M	+68,894	+235%
43	43 Deutsche Bank Frankfurt Am Main Ge, Germany	$51.3M	-$44.9M	-94,042	-49%
44	44 Westfield Capital Management Boston, Massachusetts	$49.6M	+$45.3M	+94,813	New
45	LGM 45 Logos Global Management San Francisco, California	$44.5M	+$40.6M	+85,000	New
46	CS 46 Candriam SCA Strassen, Luxembourg, Luxembourg	$44.5M	+$10.1M	+21,042	+33%
47	47 Alkeon Capital Management New York	$41.9M	-$76.4M	-160,000	-67%
48	48 New York State Common Retirement Fund Albany, New York	$39.3M	-$384K	-804	-1%
49	49 Franklin Resources San Mateo, California	$38.8M	-$5.75M	-12,035	-14%
50	50 Renaissance Technologies New York	$37.6M	-$5.73M	-11,992	-14%