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Madrigal Pharmaceuticals

352 hedge funds and large institutions have $10.7B invested in Madrigal Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 87 funds opening new positions, 107 increasing their positions, 107 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

135% more first-time investments, than exits

New positions opened: 87 | Existing positions closed: 37

50% more capital invested

Capital invested by funds: $7.13B → $10.7B (+$3.6B)

27% more call options, than puts

Call options by funds: $326M | Put options by funds: $258M

17% more funds holding in top 10

Funds holding in top 10: 1214 (+2)

15% more funds holding

Funds holding: 305352 (+47)

0% more repeat investments, than reductions

Existing positions increased: 107 | Existing positions reduced: 107

0.74% less ownership

Funds ownership: 106.08%105.34% (-0.74%)

Holders
352
Holders Change
+47
Holders Change %
+15.41%
% of All Funds
4.62%
Holding in Top 10
14
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+16.67%
% of All Funds
0.18%
New
87
Increased
107
Reduced
107
Closed
37
Calls
$326M
Puts
$258M
Net Calls
+$68.8M
Net Calls Change
-$69.9M
Name Holding Trade Value Shares
Change
Change in
Stake
Northern Trust
26
Northern Trust
Illinois
$73.4M +$6.39M +17,120 +12%
RSCM
27
Rock Springs Capital Management
Maryland
$63.2M -$951K -2,550 -2%
Fiera Capital (Canada)
28
Fiera Capital (Canada)
Quebec, Canada
$58.6M -$1.05M -2,822 -2%
ACH
29
ArrowMark Colorado Holdings
Colorado
$56.5M -$8.04M -21,549 -15%
Renaissance Technologies
30
Renaissance Technologies
New York
$55.4M +$41M +109,846 +1,014%
Alkeon Capital Management
31
Alkeon Capital Management
New York
$55M +$44.8M +120,000 New
AC
32
Armistice Capital
New York
$55M -$1.5M -4,018 -3%
DCM
33
Driehaus Capital Management
Illinois
$53.2M +$43.3M +115,974 New
AAA
34
Affinity Asset Advisors
New York
$52.7M +$13.1M +35,000 +44%
Susquehanna International Group
35
Susquehanna International Group
Pennsylvania
$48.1M +$1.68M +4,496 +4%
WP
36
Woodline Partners
California
$47.6M -$20.8M -55,776 -35%
Lord, Abbett & Co
37
Lord, Abbett & Co
New Jersey
$46.8M +$6.69M +17,926 +21%
MB
38
MPM BioImpact
Massachusetts
$46.1M
Bank of New York Mellon
39
Bank of New York Mellon
New York
$44.8M +$3.3M +8,836 +10%
D.E. Shaw & Co
40
D.E. Shaw & Co
New York
$44.1M -$5.89M -15,799 -14%
Jane Street
41
Jane Street
New York
$43.9M +$35.7M +95,734 New
Adage Capital Partners
42
Adage Capital Partners
Massachusetts
$40.6M -$107M -287,663 -76%
Connor, Clark & Lunn Investment Management (CC&L)
43
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$39.3M -$5.34M -14,322 -14%
Balyasny Asset Management
44
Balyasny Asset Management
Illinois
$37.8M +$17.9M +47,901 +139%
Franklin Resources
45
Franklin Resources
California
$34.7M +$5.54M +14,855 +24%
EC
46
EcoR1 Capital
California
$34.4M
N
47
Nuveen
North Carolina
$33.8M +$12M +32,182 +77%
BNP Paribas Financial Markets
48
BNP Paribas Financial Markets
France
$32.5M +$642K +1,720 +2%
Raymond James Financial
49
Raymond James Financial
Florida
$32.4M +$5.84M +15,651 +28%
New York State Common Retirement Fund
50
New York State Common Retirement Fund
New York
$31.8M +$3.06M +8,211 +13%