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Madrigal Pharmaceuticals
MDGL

Overview Fund Activity

303 hedge funds and large institutions have $7.13B invested in Madrigal Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 40 funds opening new positions, 105 increasing their positions, 109 reducing their positions, and 51 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
303
Holders Change
-14
Holders Change %
-4.42%
% of All Funds
4.06%
Holding in Top 10
12
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.16%
New
40
Increased
105
Reduced
109
Closed
51
Calls
$294M
Puts
$155M
Net Calls
+$139M
Net Calls Change
-$43.4M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$62.5M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$56.6M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$55.9M
4
UBS Group
UBS Group
Switzerland
+$55.7M
5
PCH
Polar Capital Holdings
United Kingdom
+$22.8M

Top Sellers

1
Holocene Advisors
Holocene Advisors
New York
-$129M
2
Fidelity Investments
Fidelity Investments
Massachusetts
-$62.6M
3
WP
Woodline Partners
California
-$47.8M
4
ACA
Avoro Capital Advisors
New York
-$44.6M
5
Morgan Stanley
Morgan Stanley
New York
-$41.4M
Name Holding Trade Value Shares
Change 		Shares
Change %
American Century Companies
26
American Century Companies
Missouri
$50.8M +$2.87M +9,478 +6%
WP
27
Woodline Partners
California
$48.3M -$47.8M -157,810 -50%
Charles Schwab
28
Charles Schwab
California
$46.3M +$555K +1,834 +1%
ACH
29
ArrowMark Colorado Holdings
Colorado
$43.8M -$10.7M -35,301 -20%
Northern Trust
30
Northern Trust
Illinois
$43.2M -$2.43M -8,018 -5%
RSCM
31
Rock Springs Capital Management
Maryland
$42.5M -$7.99M -26,402 -16%
Fiera Capital (Canada)
32
Fiera Capital (Canada)
Quebec, Canada
$39.5M -$471K -1,557 -1%
AC
33
Armistice Capital
New York
$37.5M -$3.6M -11,883 -9%
TCM
34
Tao Capital Management
California
$34.1M – – –
D.E. Shaw & Co
35
D.E. Shaw & Co
New York
$33.9M +$3.93M +12,975 +13%
Point72 Asset Management
36
Point72 Asset Management
Connecticut
$33.6M +$13.6M +45,017 +68%
MB
37
MPM BioImpact
Massachusetts
$30.4M – – –
Susquehanna International Group
38
Susquehanna International Group
Pennsylvania
$30.4M -$12.8M -42,321 -30%
Connor, Clark & Lunn Investment Management (CC&L)
39
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$30.3M -$685K -2,265 -2%
TLP
40
Tri Locum Partners
New York
$29.6M +$18.1M +59,896 +158%
Bank of New York Mellon
41
Bank of New York Mellon
New York
$26.9M +$8.52M +28,154 +46%
Lord, Abbett & Co
42
Lord, Abbett & Co
New Jersey
$25.5M -$10.2M -33,807 -29%
AAA
43
Affinity Asset Advisors
New York
$24.2M – – –
EC
44
EcoR1 Capital
California
$22.7M – – –
Mirae Asset Global Investments
45
Mirae Asset Global Investments
South Korea
$21.4M +$66K +218 +0.3%
BNP Paribas Financial Markets
46
BNP Paribas Financial Markets
France
$20.9M +$19.8M +65,561 +1,886%
Barclays
47
Barclays
United Kingdom
$19M +$4.78M +15,803 +34%
New York State Common Retirement Fund
48
New York State Common Retirement Fund
New York
$18.5M +$4.93M +16,291 +36%
B
49
Braidwell
Connecticut
$18.4M +$3.66M +12,091 +25%
Franklin Resources
50
Franklin Resources
California
$18.4M +$12.6M +41,762 +220%
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