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Immunome
IMNM

182 hedge funds and large institutions have $2.54B invested in Immunome in 2025 Q4 according to their latest regulatory filings, with 50 funds opening new positions, 77 increasing their positions, 36 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed

150% more first-time investments, than exits

New positions opened: 50 | Existing positions closed: 20

137% more capital invested

Capital invested by funds: $1.07B → $2.54B (+$1.47B)

114% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 36

25% more funds holding in top 10

Funds holding in top 10: 4 → 5 (+1)

24.05% more ownership

Funds ownership: 104.99% → 129.03% (+24%)

19% more funds holding

Funds holding: 153 → 182 (+29)

57% less call options, than puts

Call options by funds: $22.2M | Put options by funds: $51.7M

Holders
182
Holders Change
+29
Holders Change %
+18.95%
% of All Funds
2.21%
Holding in Top 10
5
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+25%
% of All Funds
0.06%
New
50
Increased
77
Reduced
36
Closed
20
Calls
$22.2M
Puts
$51.7M
Net Calls
-$29.5M
Net Calls Change
+$16.3M

Top Buyers

1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$87.8M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$61.3M
3
DCM
Driehaus Capital Management
Illinois
+$52.8M
4
JP Morgan Chase
JP Morgan Chase
New York
+$49.5M
5
Point72 Asset Management
Point72 Asset Management
Connecticut
+$38.8M

Top Sellers

1
OM
Opaleye Management
Massachusetts
-$37.3M
2
EC
EcoR1 Capital
California
-$21.5M
3
CM
Caption Management
Oklahoma
-$18.2M
4
Toronto Dominion Bank
Toronto Dominion Bank
Ontario, Canada
-$12.1M
5
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$6.36M
Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$355M +$61.3M +3,493,007 +27%
T. Rowe Price Investment Management
2
T. Rowe Price Investment Management
Maryland
$288M +$87.8M +5,003,824 +59%
BlackRock
3
BlackRock
New York
$163M +$31.1M +1,772,260 +30%
Point72 Asset Management
4
Point72 Asset Management
Connecticut
$151M +$38.8M +2,210,448 +46%
Vanguard Group
5
Vanguard Group
Pennsylvania
$130M +$20.1M +1,144,788 +23%
RG
6
Redmile Group
California
$123M +$12.2M +695,000 +14%
ES
7
Enavate Sciences
California
$102M – – –
Primecap Management
8
Primecap Management
California
$101M +$29.3M +1,667,432 +55%
State Street
9
State Street
Massachusetts
$83.1M +$18.7M +1,064,027 +38%
DCM
10
Driehaus Capital Management
Illinois
$79.6M +$52.8M +3,009,423 +432%
T. Rowe Price Associates
11
T. Rowe Price Associates
Maryland
$72.6M -$6.36M -362,530 -10%
JP Morgan Chase
12
JP Morgan Chase
New York
$61.3M +$49.5M +2,823,144 +8,659%
EC
13
EcoR1 Capital
California
$61.3M -$21.5M -1,223,825 -30%
Geode Capital Management
14
Geode Capital Management
Massachusetts
$50.7M +$8.19M +466,806 +25%
JFG
15
Jefferies Financial Group
New York
$43M -$1.76M -100,000 -5%
RAM
16
Readystate Asset Management
Illinois
$39.6M +$9.21M +524,920 +40%
Citadel Advisors
17
Citadel Advisors
Florida
$37.4M +$15.8M +899,567 +107%
Morgan Stanley
18
Morgan Stanley
New York
$36.7M -$2.19M -124,729 -7%
SI
19
Sofinnova Investments
California
$34.8M +$20.8M +1,182,426 +271%
WP
20
Woodline Partners
California
$33.8M +$5.28M +300,669 +24%
Balyasny Asset Management
21
Balyasny Asset Management
Illinois
$30.7M +$25.1M +1,429,680 New
Principal Financial Group
22
Principal Financial Group
Iowa
$30.2M +$5.26M +299,512 +27%
SCM
23
Silverarc Capital Management
Massachusetts
$24.2M +$19.8M +1,126,210 New
Wellington Management Group
24
Wellington Management Group
Massachusetts
$20.1M +$11.9M +680,395 +268%
Charles Schwab
25
Charles Schwab
California
$18.1M +$3.11M +177,077 +27%
1
2 3 4 5

IMNM Hedge Fund Activity: Q4 2025 in Review

182 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Immunome (IMNM) for Q4 2025, worth a combined $2.54B — up 137% from $1.07B a quarter earlier.

Buyers outnumbered sellers: 50 funds opened new IMNM positions and 20 closed out — a net gain of 30 holders — while 77 added to existing stakes and 36 trimmed.

The largest buyer was T. Rowe Price Investment Management, adding an estimated $87.8M. The largest seller was Opaleye Management, exiting entirely with an estimated $37.3M sold.

  • 182 institutional investors held Immunome (IMNM) as of Q4 2025, up from 153 in Q3 2025.
  • Funds reported $2.54B of Immunome stock for Q4 2025, up 137% quarter-over-quarter.
  • 50 funds opened new Immunome positions in Q4 2025 and 20 closed out, a net change of +30 holders.
  • The largest Immunome buyer in Q4 2025 was T. Rowe Price Investment Management, an estimated $87.8M added.
  • The largest Immunome seller in Q4 2025 was Opaleye Management, an estimated $37.3M sold.

Based on aggregated 13F filings for Q4 2025.