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Fractyl Health
GUTS

97 hedge funds and large institutions have $247M invested in Fractyl Health in 2025 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 32 increasing their positions, 18 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

313% more first-time investments, than exits

New positions opened: 33 | Existing positions closed: 8

78% more repeat investments, than reductions

Existing positions increased: 32 | Existing positions reduced: 18

70% more capital invested

Capital invested by funds: $145M → $247M (+$102M)

31% more funds holding

Funds holding: 74 → 97 (+23)

0% more funds holding in top 10

Funds holding in top 10: 4 → 4 (0)

99.9% less ownership

Funds ownership: 181.94% → 82.04% (-100%)

Holders
97
Holders Change
+23
Holders Change %
+31.08%
% of All Funds
1.18%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
33
Increased
32
Reduced
18
Closed
8
Calls
$3.14M
Puts
–
Net Calls
+$3.14M
Net Calls Change
+$3.14M

Top Buyers

Rank Fund Capital Flow
1
Marshall Wace
Marshall Wace
United Kingdom
+$6.69M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$6.61M
3
PFCS
Pale Fire Capital SE
Czech Republic
+$5.17M
4
Goldman Sachs
Goldman Sachs
New York
+$4.72M
5
AI
Atom Investors
Texas
+$3.03M

Top Sellers

Rank Fund Capital Flow
1
RA
Rosalind Advisors
Ontario, Canada
-$7.43M
2
SCM
Soleus Capital Management
Connecticut
-$3.38M
3
Alyeska Investment Group
Alyeska Investment Group
Illinois
-$2.96M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
-$2.93M
5
Citadel Advisors
Citadel Advisors
Florida
-$2.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
NM
26
Newtyn Management
New York
$2.49M +$1.83M +1,134,021 New
UBS Group
27
UBS Group
Switzerland
$2.45M +$582K +361,386 +48%
IC
28
Ikarian Capital
Texas
$2.42M -$1.13M -700,000 -39%
LGM
29
Logos Global Management
California
$2.42M +$966K +600,000 +120%
Massachusetts Financial Services
30
Massachusetts Financial Services
Massachusetts
$1.88M -$118K -73,505 -8%
CM
31
CM Management
Florida
$1.76M +$322K +200,000 +33%
Susquehanna International Group
32
Susquehanna International Group
Pennsylvania
$1.76M +$1.29M +799,457 New
Morgan Stanley
33
Morgan Stanley
New York
$1.44M +$364K +226,251 +53%
Walleye Capital
34
Walleye Capital
New York
$1.3M +$953K +592,125 New
State Street
35
State Street
Massachusetts
$1.13M +$760K +471,900 +1,157%
DC
36
Diametric Capital
Massachusetts
$1.11M +$608K +377,780 +301%
BGM
37
Burkehill Global Management
New York
$1.1M – – –
BHCM
38
Brevan Howard Capital Management
Jersey
$1.05M +$748K +464,738 New
SCM
39
Soleus Capital Management
Connecticut
$880K -$3.38M -2,100,000 -84%
RA
40
Rosalind Advisors
Ontario, Canada
$849K -$7.43M -4,614,269 -92%
Point72 Asset Management
41
Point72 Asset Management
Connecticut
$803K -$2.93M -1,822,826 -83%
QC
42
Quadrature Capital
United Kingdom
$640K +$446K +277,174 +2,047%
BFM
43
Boothbay Fund Management
New York
$605K -$612K -379,981 -58%
Barclays
44
Barclays
United Kingdom
$535K +$392K +243,294 New
Citadel Advisors
45
Citadel Advisors
Florida
$504K -$2.5M -1,553,371 -87%
Northern Trust
46
Northern Trust
Illinois
$475K +$324K +201,237 +1,375%
PEAK6
47
PEAK6
Illinois
$440K -$80.5K -50,000 -20%
GCP
48
GSA Capital Partners
United Kingdom
$416K +$16.3K +10,153 +6%
OAC
49
OMERS Administration Corp
Ontario, Canada
$394K +$289K +179,300 New
ECM
50
ExodusPoint Capital Management
New York
$392K +$287K +178,024 New
1
2
3 4 5

GUTS Hedge Fund Activity: Q4 2025 in Review

97 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in Fractyl Health (GUTS) for Q4 2025, worth a combined $247M — up 70% from $145M a quarter earlier.

Buyers outnumbered sellers: 33 funds opened new GUTS positions and 8 closed out — a net gain of 25 holders — while 32 added to existing stakes and 18 trimmed.

The largest buyer was Marshall Wace, adding an estimated $6.69M. The largest seller was Rosalind Advisors, cutting an estimated $7.43M.

  • 97 institutional investors held Fractyl Health (GUTS) as of Q4 2025, up from 74 in Q3 2025.
  • Funds reported $247M of Fractyl Health stock for Q4 2025, up 70% quarter-over-quarter.
  • 33 funds opened new Fractyl Health positions in Q4 2025 and 8 closed out, a net change of +25 holders.
  • The largest Fractyl Health buyer in Q4 2025 was Marshall Wace, an estimated $6.69M added.
  • The largest Fractyl Health seller in Q4 2025 was Rosalind Advisors, an estimated $7.43M sold.

Based on aggregated 13F filings for Q4 2025.