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Structure Therapeutics
GPCR

Overview Fund Activity

151 hedge funds and large institutions have $981M invested in Structure Therapeutics in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 46 increasing their positions, 50 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
151
Holders Change
-12
Holders Change %
-7.36%
% of All Funds
2.05%
Holding in Top 10
1
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-80%
% of All Funds
0.01%
New
24
Increased
46
Reduced
50
Closed
35
Calls
$12.4M
Puts
$11.7M
Net Calls
+$750K
Net Calls Change
-$10.1M

Top Buyers

1
DTC
1
Deep Track Capital
Connecticut
$71M
2
Morgan Stanley
2
Morgan Stanley
New York
$12M
3
RAM
3
Readystate Asset Management
Illinois
$8.33M
4
Janus Henderson Group
4
Janus Henderson Group
United Kingdom
$86.1M
5
Handelsbanken Fonder
5
Handelsbanken Fonder
Sweden
$6.58M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$37.5M
2
Federated Hermes
2
Federated Hermes
Pennsylvania
$20.3M
3
DCM
3
Driehaus Capital Management
Illinois
$22M
4
BCM
4
Boxer Capital Management
California
$0
5
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$13.5M
Name Holding Trade Value Shares
Change 		Shares
Change %
PAS
151
Point72 Asia (Singapore)
Singapore
$17 – – –
BCM
152
Boxer Capital Management
California
– -$13.6M -500,000 Closed
Ensign Peak Advisors
153
Ensign Peak Advisors
Utah
– -$8.36M -308,241 Closed
SCM
154
Superstring Capital Management
New York
– -$5.88M -216,811 Closed
AllianceBernstein
155
AllianceBernstein
Tennessee
– -$3.87M -142,825 Closed
RI
156
RTW Investments
New York
– -$3.39M -125,000 Closed
FAM
157
Fred Alger Management
New York
– -$1.81M -66,662 Closed
Russell Investments Group
158
Russell Investments Group
United Kingdom
– -$940K -34,671 Closed
TC
159
TwinBeech Capital
New York
– -$767K -28,268 Closed
MCC
160
Money Concepts Capital
Florida
– -$570K -21,031 Closed
UOC
161
UBS O'Connor
Illinois
– -$529K -19,520 Closed
M&T Bank
162
M&T Bank
New York
– -$492K -18,110 Closed
EGM
163
Engineers Gate Manager
New York
– -$458K -16,880 Closed
JGC
164
J. Goldman & Co
New York
– -$458K -16,873 Closed
Natixis Advisors
165
Natixis Advisors
Massachusetts
– -$392K -14,459 Closed
GAM
166
Griffin Asset Management
New York
– -$392K -14,450 Closed
Walleye Trading
167
Walleye Trading
New York
– -$366K -13,485 Closed
EC
168
EntryPoint Capital
New York
– -$360K -13,260 Closed
Walleye Capital
169
Walleye Capital
New York
– -$316K -11,656 Closed
LPL Financial
170
LPL Financial
California
– -$311K -11,485 Closed
CCM
171
Cinctive Capital Management
New York
– -$246K -9,065 Closed
JCM
172
Janney Capital Management
Pennsylvania
– -$244K -9,007 Closed
SWM
173
Spire Wealth Management
Virginia
– -$243K -8,949 Closed
Allianz Asset Management
174
Allianz Asset Management
Germany
– -$239K -8,800 Closed
QWM
175
Quadcap Wealth Management
Texas
– -$213K -7,851 Closed
4 5 6
7
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