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Structure Therapeutics
GPCR

Overview Fund Activity

151 hedge funds and large institutions have $981M invested in Structure Therapeutics in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 46 increasing their positions, 50 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
151
Holders Change
-12
Holders Change %
-7.36%
% of All Funds
2.05%
Holding in Top 10
1
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-80%
% of All Funds
0.01%
New
24
Increased
46
Reduced
50
Closed
35
Calls
$12.4M
Puts
$11.7M
Net Calls
+$750K
Net Calls Change
-$10.1M

Top Buyers

1
DTC
1
Deep Track Capital
Connecticut
$71M
2
Morgan Stanley
2
Morgan Stanley
New York
$12M
3
RAM
3
Readystate Asset Management
Illinois
$8.33M
4
Janus Henderson Group
4
Janus Henderson Group
United Kingdom
$86.1M
5
Handelsbanken Fonder
5
Handelsbanken Fonder
Sweden
$6.58M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$37.5M
2
Federated Hermes
2
Federated Hermes
Pennsylvania
$20.3M
3
DCM
3
Driehaus Capital Management
Illinois
$22M
4
BCM
4
Boxer Capital Management
California
$0
5
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$13.5M
Name Holding Trade Value Shares
Change 		Shares
Change %
Renaissance Technologies
101
Renaissance Technologies
New York
$273K +$273K +15,800 New
QT
102
Quantbot Technologies
New York
$249K +$249K +14,401 New
GLA
103
Good Life Advisors
Pennsylvania
$225K +$225K +13,000 New
CUAMC
104
China Universal Asset Management Company
China
$207K -$11.8K -683 -5%
GCM
105
Graham Capital Management
Connecticut
$206K +$206K +11,908 New
D.E. Shaw & Co
106
D.E. Shaw & Co
New York
$202K +$202K +11,661 New
BM
107
Brandywine Managers
Delaware
$191K – – –
State Street
108
State Street
Massachusetts
$186K +$3.69K +213 +2%
BL
109
Bleichroeder LP
New York
$173K – – –
PEAK6
110
PEAK6
Illinois
$163K – – –
CM
111
Caption Management
Oklahoma
$160K +$63.3K +3,656 +65%
Wells Fargo
112
Wells Fargo
California
$127K -$47.7K -2,758 -27%
UBS AM
113
UBS AM
Illinois
$102K +$102K +5,915 New
Barclays
114
Barclays
United Kingdom
$92K -$1.91M -110,359 -95%
VIA
115
Virtus Investment Advisers
Connecticut
$89.6K +$89.6K +5,177 New
BNP Paribas Financial Markets
116
BNP Paribas Financial Markets
France
$78.2K -$116K -6,700 -60%
AP
117
Antipodes Partners
Australia
$73.5K +$55.6K +3,213 +311%
Mirae Asset Global Investments
118
Mirae Asset Global Investments
South Korea
$72.9K +$2.35K +119 +3%
Royal Bank of Canada
119
Royal Bank of Canada
Ontario, Canada
$64K -$2.1M -121,981 -97%
Jones Financial Companies
120
Jones Financial Companies
Missouri
$62.2K -$21.4K -1,082 -26%
PNC Financial Services Group
121
PNC Financial Services Group
Pennsylvania
$59.2K +$2.49K +144 +4%
PCM
122
Penserra Capital Management
California
$59K +$5.26K +304 +10%
HT
123
Headlands Technologies
Illinois
$59K -$13K -752 -18%
National Bank of Canada
124
National Bank of Canada
Quebec, Canada
$51.1K +$47.8K +2,766 +1,448%
SPIA
125
Steward Partners Investment Advisory
New York
$43.6K +$6.96K +402 +19%
3 4
5
6 7