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Structure Therapeutics
GPCR

Overview Fund Activity

172 hedge funds and large institutions have $1.13B invested in Structure Therapeutics in 2025 Q2 according to their latest regulatory filings, with 38 funds opening new positions, 62 increasing their positions, 44 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
172
Holders Change
+21
Holders Change %
+13.91%
% of All Funds
2.31%
Holding in Top 10
3
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+200%
% of All Funds
0.04%
New
38
Increased
62
Reduced
44
Closed
17
Calls
$12.5M
Puts
$10.5M
Net Calls
+$1.95M
Net Calls Change
+$1.2M

Top Buyers

1
BBA
1
Baker Bros. Advisors
New York
$52M
2
DTC
2
Deep Track Capital
Connecticut
$106M
3
O
3
OrbiMed
New York
$24.9M
4
CC
4
Casdin Capital
New York
$25.4M
5
PHAM
5
Pacific Heights Asset Management
California
$9.54M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$0
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$102M
3
Fidelity International
3
Fidelity International
Bermuda
$0
4
Wellington Management Group
4
Wellington Management Group
Massachusetts
$143M
5
Federated Hermes
5
Federated Hermes
Pennsylvania
$9.71M
Name Holding Trade Value Shares
Change 		Shares
Change %
RPAM
51
Rhenman & Partners Asset Management
Sweden
$2.8M +$1.35M +65,100 +93%
FLAM
52
First Light Asset Management
Minnesota
$2.53M -$211K -10,154 -8%
PE
53
Point72 Europe
United Kingdom
$2.42M +$539K +26,000 +29%
Renaissance Technologies
54
Renaissance Technologies
New York
$2.32M +$1.99M +96,100 +608%
EP
55
Eversept Partners
New York
$2.06M +$2.06M +99,338 New
SFM
56
Sphera Funds Management
Israel
$1.99M +$247K +11,931 +14%
HS
57
HighVista Strategies
Massachusetts
$1.8M +$1.43M +69,060 +393%
TI
58
Trexquant Investment
Connecticut
$1.69M -$804K -38,752 -32%
Susquehanna International Group
59
Susquehanna International Group
Pennsylvania
$1.57M +$158K +7,635 +11%
PIM
60
Platinum Investment Management
Australia
$1.55M – – –
Verition Fund Management
61
Verition Fund Management
Connecticut
$1.51M +$1.11M +53,402 +273%
CSS
62
Cubist Systematic Strategies
Connecticut
$1.49M +$350K +16,874 +31%
BPC
63
Banque Pictet & Cie
Switzerland
$1.46M -$236K -11,365 -14%
JG
64
Jain Global
New York
$1.44M +$948K +45,730 +193%
BNP Paribas Financial Markets
65
BNP Paribas Financial Markets
France
$1.37M +$1.27M +61,318 +1,357%
JF
66
Jump Financial
Illinois
$1.31M +$675K +32,524 +106%
ETC
67
Exchange Traded Concepts
Oklahoma
$1.28M +$473K +22,809 +59%
Bank of Montreal
68
Bank of Montreal
Ontario, Canada
$1.22M +$102K +4,838 +9%
DCM
69
DAFNA Capital Management
California
$1.22M – – –
Macquarie Group
70
Macquarie Group
Australia
$1.2M – – –
BFM
71
Boothbay Fund Management
New York
$1.2M -$408K -19,672 -25%
PHS
72
PFM Health Sciences
California
$1.17M +$336K +16,194 +40%
Geode Capital Management
73
Geode Capital Management
Massachusetts
$1.12M +$175K +8,444 +18%
EAM
74
Exome Asset Management
New York
$1.11M -$1.02M -49,200 -48%
SAM
75
Sectoral Asset Management
Quebec, Canada
$1.07M +$367K +17,674 +52%
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