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Structure Therapeutics
GPCR

Overview Fund Activity

172 hedge funds and large institutions have $1.13B invested in Structure Therapeutics in 2025 Q2 according to their latest regulatory filings, with 38 funds opening new positions, 62 increasing their positions, 44 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
172
Holders Change
+21
Holders Change %
+13.91%
% of All Funds
2.31%
Holding in Top 10
3
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+200%
% of All Funds
0.04%
New
38
Increased
62
Reduced
44
Closed
17
Calls
$12.5M
Puts
$10.5M
Net Calls
+$1.95M
Net Calls Change
+$1.2M

Top Buyers

1
BBA
1
Baker Bros. Advisors
New York
$52M
2
DTC
2
Deep Track Capital
Connecticut
$106M
3
O
3
OrbiMed
New York
$24.9M
4
CC
4
Casdin Capital
New York
$25.4M
5
PHAM
5
Pacific Heights Asset Management
California
$9.54M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$0
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$102M
3
Fidelity International
3
Fidelity International
Bermuda
$0
4
Wellington Management Group
4
Wellington Management Group
Massachusetts
$143M
5
Federated Hermes
5
Federated Hermes
Pennsylvania
$9.71M
Name Holding Trade Value Shares
Change 		Shares
Change %
MIM
26
Monashee Investment Management
Massachusetts
$8.92M +$2.84M +137,138 +47%
Invesco
27
Invesco
Georgia
$8.81M +$626K +30,162 +8%
Aberdeen Group
28
Aberdeen Group
United Kingdom
$8.33M +$3.17M +152,725 +61%
Handelsbanken Fonder
29
Handelsbanken Fonder
Sweden
$7.88M – – –
DM
30
Deerfield Management
New York
$7.74M – – –
T. Rowe Price Associates
31
T. Rowe Price Associates
Maryland
$7.32M -$8.8M -424,305 -55%
BG
32
Bellevue Group
Switzerland
$7.23M +$2.63M +126,812 +57%
Point72 Asset Management
33
Point72 Asset Management
Connecticut
$6.84M +$2.09M +100,569 +44%
SSA
34
Schonfeld Strategic Advisors
New York
$6.67M +$6.67M +321,591 New
ACH
35
ArrowMark Colorado Holdings
Colorado
$6.2M +$1.11M +53,751 +22%
HH
36
HSG Holding
Hong Kong
$5.52M – – –
BlackRock
37
BlackRock
New York
$5.05M -$6.7M -323,171 -57%
Goldman Sachs
38
Goldman Sachs
New York
$4.57M -$2.16M -104,261 -32%
FCMV
39
Foresite Capital Management VI
California
$4.36M -$4.36M -210,000 -50%
PC
40
Pier Capital
Connecticut
$4.12M -$291K -14,042 -7%
IC
41
Ikarian Capital
Texas
$3.8M -$1.68M -81,000 -31%
RAM
42
Readystate Asset Management
Illinois
$3.7M -$6.28M -302,629 -63%
WP
43
Woodline Partners
California
$3.66M +$21.3K +1,029 +0.6%
Marshall Wace
44
Marshall Wace
United Kingdom
$3.65M +$3.02M +145,434 +475%
SCM
45
Silverarc Capital Management
Massachusetts
$3.64M -$258K -12,433 -7%
NCM
46
Nantahala Capital Management
Connecticut
$3.5M – – –
Canada Pension Plan Investment Board
47
Canada Pension Plan Investment Board
Ontario, Canada
$3.48M +$3.48M +167,800 New
UBS Group
48
UBS Group
Switzerland
$3.17M -$1.77M -85,216 -36%
CWM
49
CCG Wealth Management
California
$3.11M – – –
SFI
50
Susquehanna Fundamental Investments
Pennsylvania
$2.9M -$378K -18,244 -12%
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