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Structure Therapeutics

GPCR

Market cap $3.6B

196 hedge funds and large institutions have $3.22B invested in Structure Therapeutics in 2026 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 73 increasing their positions, 58 reducing their positions, and 39 closing their positions.

New

Increased

Maintained

Reduced

Closed

45% more call options, than puts

Call options by funds: $27.4M | Put options by funds: $18.9M

26% more repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 58

0% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 39

1% less funds holding

Funds holding: 197 → 196 (-1)

14.16% less ownership

Funds ownership: 108.4% → 94.24% (-14%)

30% less capital invested

Capital invested by funds: $4.58B → $3.22B (-$1.36B)

63% less funds holding in top 10

Funds holding in top 10: 16 → 6 (-10)

Holders

196

Holders Change

-1

Holders Change %

-0.51%

% of All Funds

2.41%

Holding in Top 10

Holding in Top 10 Change

-10

Holding in Top 10 Change %

-62.5%

% of All Funds

0.07%

New

Increased

Reduced

Closed

Calls

$27.4M

Puts

$18.9M

Net Calls

+$8.44M

Net Calls Change

-$35.9M

Top Buyers

1	American Century Companies Kansas City, Missouri	+$63.7M
2	PBA Paradigm Biocapital Advisors New York	+$37.3M
3	Principal Financial Group Des Moines, Iowa	+$32.1M
4	T. Rowe Price Associates Baltimore, Maryland	+$22.6M
5	O OrbiMed New York	+$21.5M

Top Sellers

1	TCM TCG Crossover Management Palo Alto, California	-$53.4M
2	Citadel Advisors Miami, Florida	-$52.9M
3	Deutsche Bank Frankfurt Am Main Ge, Germany	-$34.9M
4	FCM Farallon Capital Management San Francisco, California	-$31.6M
5	EC EcoR1 Capital San Francisco, California	-$23.3M

#	Name	Holding	Trade Value	Shares Change	Change in Stake
226	226 CIBC World Market Toronto, Ontario, Canada	–	-$226K	-3,248	Closed
227	227 ProShare Advisors Bethesda, Maryland	–	-$206K	-2,957	Closed
228	BCV 228 Banque Cantonale Vaudoise Lausanne, Switzerland	–	-$205K	-2,945	Closed
229	PFSRSONJ 229 Police & Firemen's Retirement System of New Jersey Trenton, New Jersey	–	-$127K	-1,829	Closed
230	CTB 230 Country Trust Bank Bloomington, Illinois	–	-$34.8K	-500	Closed
231	PWMG 231 Private Wealth Management Group Princeton, New Jersey	–	-$13.6K	-196	Closed
232	232 Daiwa Securities Group Tokyo, Japan	–	-$13K	-186	Closed
233	233 Northwestern Mutual Wealth Management Milwaukee, Wisconsin	–	-$4.17K	-60	Closed
234	234 Bessemer Group Woodbridge, New Jersey	–	-$2K	-29	Closed
235	BAM 235 Bellevue Asset Management Bellevue, Washington	–	-$1.04K	-15	Closed