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Fulcrum Therapeutics
FULC

122 hedge funds and large institutions have $374M invested in Fulcrum Therapeutics in 2025 Q2 according to their latest regulatory filings, with 24 funds opening new positions, 34 increasing their positions, 46 reducing their positions, and 19 closing their positions.

New
Increased
Maintained
Reduced
Closed

874% more call options, than puts

Call options by funds: $6.27M | Put options by funds: $643K

152% more capital invested

Capital invested by funds: $148M → $374M (+$226M)

26% more first-time investments, than exits

New positions opened: 24 | Existing positions closed: 19

5.62% more ownership

Funds ownership: 95.16% → 100.78% (+5.6%)

4% more funds holding

Funds holding: 117 → 122 (+5)

26% less repeat investments, than reductions

Existing positions increased: 34 | Existing positions reduced: 46

Holders
122
Holders Change
+5
Holders Change %
+4.27%
% of All Funds
1.61%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
% of All Funds
0.03%
New
24
Increased
34
Reduced
46
Closed
19
Calls
$6.27M
Puts
$643K
Net Calls
+$5.62M
Net Calls Change
+$5.51M

Top Buyers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$8.5M
2
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$7.16M
3
Goldman Sachs
Goldman Sachs
New York
+$3.96M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$3.19M
5
Point72 Asset Management
Point72 Asset Management
Connecticut
+$2.66M

Top Sellers

Rank Fund Capital Flow
1
NCM
Nantahala Capital Management
Connecticut
-$2.86M
2
ACM
ADAR1 Capital Management
Texas
-$2.34M
3
BlackRock
BlackRock
New York
-$1.77M
4
Renaissance Technologies
Renaissance Technologies
New York
-$1.73M
5
EAM
Exome Asset Management
New York
-$1.31M
Name Holding Trade Value Shares
Change 		Change in
Stake
HF
126
HRT Financial
New York
– -$145K -50,490 Closed
XT
127
XTX Topco
Cayman Islands
– -$144K -49,878 Closed
AG
128
Algert Global
California
– -$104K -36,147 Closed
YIH
129
Y-Intercept (HK)
Hong Kong
– -$92.4K -32,086 Closed
CF
130
Corebridge Financial
Texas
– -$76K -26,381 Closed
SG Americas Securities
131
SG Americas Securities
New York
– -$73K -25,375 Closed
ZIM
132
Zacks Investment Management
Illinois
– -$60.5K -20,999 Closed
VF
133
Virtu Financial
New York
– -$39K -13,564 Closed
JG
134
Jain Global
New York
– -$37.6K -13,051 Closed
EGM
135
Engineers Gate Manager
New York
– -$36.1K -12,519 Closed
CWM
136
CIBC World Markets
New York
– -$34.4K -11,949 Closed
JF
137
Jump Financial
Illinois
– -$30.4K -10,550 Closed
CIAM
138
Caitong International Asset Management
Hong Kong
– -$4.34K -1,507 Closed
SPIA
139
Steward Partners Investment Advisory
New York
– -$2.27K -790 Closed
UBS AM
140
UBS AM
Illinois
– -$2.02K -703 Closed
CCM
141
Coldstream Capital Management
Washington
– -$302 -105 Closed
2 3 4 5
6

FULC Hedge Fund Activity: Q2 2025 in Review

122 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Fulcrum Therapeutics (FULC) for Q2 2025, worth a combined $374M — up 152% from $148M a quarter earlier.

Buyers outnumbered sellers: 24 funds opened new FULC positions and 19 closed out — a net gain of 5 holders — while 34 added to existing stakes and 46 trimmed.

The largest buyer was Adage Capital Partners, adding an estimated $8.5M. The largest seller was Nantahala Capital Management, cutting an estimated $2.86M.

  • 122 institutional investors held Fulcrum Therapeutics (FULC) as of Q2 2025, up from 117 in Q1 2025.
  • Funds reported $374M of Fulcrum Therapeutics stock for Q2 2025, up 152% quarter-over-quarter.
  • 24 funds opened new Fulcrum Therapeutics positions in Q2 2025 and 19 closed out, a net change of +5 holders.
  • The largest Fulcrum Therapeutics buyer in Q2 2025 was Adage Capital Partners, an estimated $8.5M added.
  • The largest Fulcrum Therapeutics seller in Q2 2025 was Nantahala Capital Management, an estimated $2.86M sold.

Based on aggregated 13F filings for Q2 2025.