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Fulcrum Therapeutics
FULC

129 hedge funds and large institutions have $496M invested in Fulcrum Therapeutics in 2025 Q3 according to their latest regulatory filings, with 26 funds opening new positions, 40 increasing their positions, 43 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

1,213% more call options, than puts

Call options by funds: $1.64M | Put options by funds: $125K

44% more first-time investments, than exits

New positions opened: 26 | Existing positions closed: 18

32% more capital invested

Capital invested by funds: $374M → $496M (+$121M)

6% more funds holding

Funds holding: 122 → 129 (+7)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

7% less repeat investments, than reductions

Existing positions increased: 40 | Existing positions reduced: 43

1.34% less ownership

Funds ownership: 100.78% → 99.44% (-1.3%)

Holders
129
Holders Change
+7
Holders Change %
+5.74%
% of All Funds
1.69%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
26
Increased
40
Reduced
43
Closed
18
Calls
$1.64M
Puts
$125K
Net Calls
+$1.52M
Net Calls Change
-$4.11M

Top Buyers

Rank Fund Capital Flow
1
Royal Bank of Canada
Royal Bank of Canada
Ontario, Canada
+$7.21M
2
IC
Ikarian Capital
Texas
+$6.23M
3
Citadel Advisors
Citadel Advisors
Florida
+$4.98M
4
BFM
Boothbay Fund Management
New York
+$3.89M
5
NCM
Nantahala Capital Management
Connecticut
+$2.77M

Top Sellers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$15.6M
2
WP
Woodline Partners
California
-$6.18M
3
BlackRock
BlackRock
New York
-$4.86M
4
Goldman Sachs
Goldman Sachs
New York
-$4.03M
5
Point72 Asset Management
Point72 Asset Management
Connecticut
-$3.43M
Name Holding Trade Value Shares
Change 		Change in
Stake
Bessemer Group
26
Bessemer Group
New Jersey
$2.64M – – –
Deutsche Bank
27
Deutsche Bank
Germany
$2.63M +$44K +6,078 +2%
Renaissance Technologies
28
Renaissance Technologies
New York
$2.28M +$1.23M +169,700 +216%
Morgan Stanley
29
Morgan Stanley
New York
$2.24M -$511K -70,575 -22%
B
30
Braidwell
Connecticut
$2.02M +$1.59M +219,488 New
Wellington Management Group
31
Wellington Management Group
Massachusetts
$1.65M +$383K +52,956 +42%
American Century Companies
32
American Century Companies
Missouri
$1.4M +$144K +19,895 +15%
Millennium Management
33
Millennium Management
New York
$1.39M +$327K +45,174 +43%
Bank of America
34
Bank of America
North Carolina
$1.35M +$732K +101,222 +220%
Aberdeen Group
35
Aberdeen Group
United Kingdom
$1.27M +$573K +79,265 +135%
FT
36
Fiduciary Trust
Massachusetts
$1.26M – – –
JGC
37
J. Goldman & Co
New York
$1.24M +$488K +67,500 +100%
HF
38
HRT Financial
New York
$1.15M +$904K +124,924 New
Ameriprise
39
Ameriprise
Minnesota
$1.15M +$902K +124,666 New
Invesco
40
Invesco
Georgia
$1.14M -$2.51M -346,461 -74%
Bank of New York Mellon
41
Bank of New York Mellon
New York
$1.1M -$129K -17,842 -13%
GCP
42
GSA Capital Partners
United Kingdom
$1.07M +$604K +83,505 +256%
N
43
Nuveen
North Carolina
$1.03M -$90.6K -12,520 -10%
SFI
44
Susquehanna Fundamental Investments
Pennsylvania
$1.03M – – –
CCIA
45
Campbell & Co Investment Adviser
Maryland
$943K +$741K +102,470 New
EAM
46
Exome Asset Management
New York
$909K -$2.5M -346,150 -78%
BCM
47
Bridgeway Capital Management
Texas
$878K -$15.9K -2,200 -2%
Barclays
48
Barclays
United Kingdom
$824K -$162K -22,447 -20%
Commonwealth Equity Services
49
Commonwealth Equity Services
Massachusetts
$768K – – –
SAM
50
Simplify Asset Management
Nevada
$766K +$72.9K +10,080 +14%
1
2
3 4 5

FULC Hedge Fund Activity: Q3 2025 in Review

129 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Fulcrum Therapeutics (FULC) for Q3 2025, worth a combined $496M — up 32% from $374M a quarter earlier.

Buyers outnumbered sellers: 26 funds opened new FULC positions and 18 closed out — a net gain of 8 holders — while 40 added to existing stakes and 43 trimmed.

The largest buyer was Royal Bank of Canada, adding an estimated $7.21M. The largest seller was Adage Capital Partners, cutting an estimated $15.6M.

  • 129 institutional investors held Fulcrum Therapeutics (FULC) as of Q3 2025, up from 122 in Q2 2025.
  • Funds reported $496M of Fulcrum Therapeutics stock for Q3 2025, up 32% quarter-over-quarter.
  • 26 funds opened new Fulcrum Therapeutics positions in Q3 2025 and 18 closed out, a net change of +8 holders.
  • The largest Fulcrum Therapeutics buyer in Q3 2025 was Royal Bank of Canada, an estimated $7.21M added.
  • The largest Fulcrum Therapeutics seller in Q3 2025 was Adage Capital Partners, an estimated $15.6M sold.

Based on aggregated 13F filings for Q3 2025.