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Amicus Therapeutics
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Overview Fund Activity

268 hedge funds and large institutions have $1.83B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 118 increasing their positions, 81 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
268
Holders Change
-13
Holders Change %
-4.63%
% of All Funds
3.59%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
118
Reduced
81
Closed
47
Calls
$2.41M
Puts
$1.56M
Net Calls
+$846K
Net Calls Change
+$2.68M

Top Buyers

1
VPC
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
Millennium Management
New York
$42.5M
4
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
$20.2M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$19.9M

Top Sellers

1
PA
Perceptive Advisors
New York
$42.5M
2
RG
Redmile Group
California
$6.81M
3
American Century Companies
American Century Companies
Missouri
$0
4
NHAS
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$12.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
DekaBank Deutsche Girozentrale
101
DekaBank Deutsche Girozentrale
Germany
$1.28M – – –
Creative Planning
102
Creative Planning
Kansas
$1.24M +$1.04M +180,652 +507%
California State Teachers Retirement System (CalSTRS)
103
California State Teachers Retirement System (CalSTRS)
California
$1.2M +$3.24K +566 +0.3%
MIM
104
MetLife Investment Management
New Jersey
$992K -$5.61K -979 -0.6%
AA
105
ALPS Advisors
Colorado
$952K -$322K -56,173 -25%
HF
106
HRT Financial
New York
$927K -$594K -103,776 -39%
Wells Fargo
107
Wells Fargo
California
$926K -$18K -3,139 -2%
HT
108
Headlands Technologies
Illinois
$914K +$593K +103,492 +185%
Tudor Investment Corp
109
Tudor Investment Corp
Connecticut
$914K +$505K +88,206 +124%
Manulife (Manufacturers Life Insurance)
110
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$870K -$61.7K -10,763 -7%
WCM
111
Wedge Capital Management
North Carolina
$829K +$5.34K +932 +0.6%
Mackenzie Financial
112
Mackenzie Financial
Ontario, Canada
$798K +$554K +96,602 +227%
GAM
113
Gotham Asset Management
New York
$782K +$473K +82,546 +153%
First Trust Advisors
114
First Trust Advisors
Illinois
$771K +$26K +4,537 +3%
IIM
115
INTECH Investment Management
Florida
$705K -$275K -47,907 -28%
EAM
116
Erste Asset Management
Austria
$693K – – –
SAM
117
Sectoral Asset Management
Quebec, Canada
$685K +$68.8K +12,000 +11%
Russell Investments Group
118
Russell Investments Group
United Kingdom
$677K -$139K -24,334 -17%
TRSOTSOK
119
Teachers Retirement System of the State of Kentucky
Kentucky
$645K +$172K +29,916 +36%
AQR Capital Management
120
AQR Capital Management
Connecticut
$639K +$396K +69,138 +163%
Victory Capital Management
121
Victory Capital Management
Texas
$593K -$880K -153,607 -60%
GC
122
Guggenheim Capital
Illinois
$576K +$88K +15,353 +18%
Pathstone Holdings
123
Pathstone Holdings
New Jersey
$574K -$619 -108 -0.1%
Ensign Peak Advisors
124
Ensign Peak Advisors
Utah
$566K – – –
BHCM
125
Brevan Howard Capital Management
Jersey
$560K +$560K +97,688 New
3 4
5
6 7