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Amicus Therapeutics
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Overview Fund Activity

268 hedge funds and large institutions have $1.83B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 118 increasing their positions, 81 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
268
Holders Change
-13
Holders Change %
-4.63%
% of All Funds
3.59%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
118
Reduced
81
Closed
47
Calls
$2.41M
Puts
$1.56M
Net Calls
+$846K
Net Calls Change
+$2.68M

Top Buyers

1
VPC
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
Millennium Management
New York
$42.5M
4
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
$20.2M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$19.9M

Top Sellers

1
PA
Perceptive Advisors
New York
$42.5M
2
RG
Redmile Group
California
$6.81M
3
American Century Companies
American Century Companies
Missouri
$0
4
NHAS
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$12.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
State of Wisconsin Investment Board
76
State of Wisconsin Investment Board
Wisconsin
$2.89M +$557K +97,185 +24%
Swiss National Bank
77
Swiss National Bank
Switzerland
$2.63M +$140K +24,500 +6%
CM
78
CM Management
Florida
$2.58M – – –
RhumbLine Advisers
79
RhumbLine Advisers
Massachusetts
$2.49M -$34.4K -5,999 -1%
Balyasny Asset Management
80
Balyasny Asset Management
Illinois
$2.42M -$2.76M -481,419 -53%
Fidelity Investments
81
Fidelity Investments
Massachusetts
$2.41M +$191K +33,314 +9%
Rafferty Asset Management
82
Rafferty Asset Management
New York
$2.38M +$924K +161,274 +64%
Allianz Asset Management
83
Allianz Asset Management
Germany
$2.22M +$93.8K +16,367 +4%
Susquehanna International Group
84
Susquehanna International Group
Pennsylvania
$2.18M -$895K -156,176 -29%
AllianceBernstein
85
AllianceBernstein
Tennessee
$2.08M – – –
Citigroup
86
Citigroup
New York
$2.04M -$517K -90,164 -20%
SSCM
87
Sovereign's Capital Management
Georgia
$2.04M +$259K +45,248 +15%
RAM
88
Readystate Asset Management
Illinois
$1.89M +$1.89M +329,917 New
DFCM
89
Dark Forest Capital Management
Puerto Rico
$1.79M -$1.81M -315,276 -50%
Universal-Beteiligungs- und Servicegesellschaft
90
Universal-Beteiligungs- und Servicegesellschaft
Germany
$1.77M +$548K +95,565 +45%
Prudential Financial
91
Prudential Financial
New Jersey
$1.57M -$884K -154,355 -36%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
92
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.56M +$1.56M +272,700 New
MOACM
93
Mutual of America Capital Management
New York
$1.56M +$132K +23,091 +9%
Mirae Asset Global ETFs Holdings
94
Mirae Asset Global ETFs Holdings
Hong Kong
$1.52M +$103K +18,002 +7%
Legal & General Group
95
Legal & General Group
United Kingdom
$1.52M +$48K +8,375 +3%
OCM
96
Osterweis Capital Management
California
$1.44M -$3.29M -573,805 -70%
ACM
97
Aquatic Capital Management
Illinois
$1.43M +$343K +59,912 +32%
SEI Investments
98
SEI Investments
Pennsylvania
$1.38M +$319K +55,601 +30%
New York State Common Retirement Fund
99
New York State Common Retirement Fund
New York
$1.37M -$101K -17,600 -7%
JFG
100
Jefferies Financial Group
New York
$1.28M +$206K +35,903 +19%
2 3
4
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