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Amicus Therapeutics
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Overview Fund Activity

268 hedge funds and large institutions have $1.83B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 118 increasing their positions, 81 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
268
Holders Change
-13
Holders Change %
-4.63%
% of All Funds
3.59%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
118
Reduced
81
Closed
47
Calls
$2.41M
Puts
$1.56M
Net Calls
+$846K
Net Calls Change
+$2.68M

Top Buyers

1
VPC
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
Millennium Management
New York
$42.5M
4
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
$20.2M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$19.9M

Top Sellers

1
PA
Perceptive Advisors
New York
$42.5M
2
RG
Redmile Group
California
$6.81M
3
American Century Companies
American Century Companies
Missouri
$0
4
NHAS
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$12.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
BNP Paribas Financial Markets
51
BNP Paribas Financial Markets
France
$7.16M +$4.28M +747,461 +149%
RG
52
Redmile Group
California
$6.81M -$47.8M -8,344,671 -88%
Barclays
53
Barclays
United Kingdom
$6.78M +$3.13M +546,637 +86%
T. Rowe Price Associates
54
T. Rowe Price Associates
Maryland
$6M -$1.36M -236,851 -18%
Schroder Investment Management Group
55
Schroder Investment Management Group
United Kingdom
$5.83M +$3.72M +649,177 +176%
PCM
56
Peregrine Capital Management
Minnesota
$5.8M +$582K +101,592 +11%
SFM
57
Sphera Funds Management
Israel
$5.68M +$5.68M +990,718 New
YIH
58
Y-Intercept (HK)
Hong Kong
$5.65M +$5.53M +965,328 +4,500%
SAM
59
Silvercrest Asset Management
New York
$5.55M +$2.49M +434,520 +81%
6CM
60
683 Capital Management
New York
$5.5M +$3.93M +685,000 +249%
Squarepoint
61
Squarepoint
New York
$5.27M -$3.56M -621,037 -40%
Two Sigma Advisers
62
Two Sigma Advisers
New York
$5.14M -$783K -136,700 -13%
TI
63
Trexquant Investment
Connecticut
$4.88M +$3.45M +601,703 +240%
SIMG
64
Stephens Investment Management Group
Texas
$4.77M +$1.26M +220,173 +36%
Bank of New York Mellon
65
Bank of New York Mellon
New York
$4.6M -$1M -175,239 -18%
Primecap Management
66
Primecap Management
California
$4.56M -$707K -123,400 -13%
Capital Fund Management (CFM)
67
Capital Fund Management (CFM)
France
$4.37M +$2.58M +450,137 +144%
Two Sigma Investments
68
Two Sigma Investments
New York
$4.2M -$3.78M -660,034 -47%
CCIA
69
Campbell & Co Investment Adviser
Maryland
$3.76M +$3.76M +656,111 New
EGM
70
Engineers Gate Manager
New York
$3.68M +$2.74M +479,038 +295%
VOYA Investment Management
71
VOYA Investment Management
Georgia
$3.59M +$240K +41,901 +7%
PHP
72
Parkman Healthcare Partners
Connecticut
$3.49M +$227K +39,685 +7%
Jane Street
73
Jane Street
New York
$3.14M -$2.1M -365,718 -40%
Canada Pension Plan Investment Board
74
Canada Pension Plan Investment Board
Ontario, Canada
$2.97M +$2.12M +369,800 +249%
PP
75
PDT Partners
New York
$2.9M -$1.35M -235,263 -32%
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