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Amicus Therapeutics
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Overview Fund Activity

281 hedge funds and large institutions have $2.53B invested in Amicus Therapeutics in 2025 Q1 according to their latest regulatory filings, with 41 funds opening new positions, 113 increasing their positions, 86 reducing their positions, and 41 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
281
Holders Change
-5
Holders Change %
-1.75%
% of All Funds
3.82%
Holding in Top 10
5
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+25%
% of All Funds
0.07%
New
41
Increased
113
Reduced
86
Closed
41
Calls
$3.21M
Puts
$5.05M
Net Calls
-$1.84M
Net Calls Change
-$1.73M

Top Buyers

1
Point72 Asset Management
1
Point72 Asset Management
Connecticut
$24.4M
2
Millennium Management
2
Millennium Management
New York
$27.4M
3
RG
3
Redmile Group
California
$77.8M
4
Bank of America
4
Bank of America
North Carolina
$45.7M
5
Two Sigma Investments
5
Two Sigma Investments
New York
$11.4M

Top Sellers

1
Fiera Capital (Canada)
1
Fiera Capital (Canada)
Quebec, Canada
$0
2
PA
2
Perceptive Advisors
New York
$175M
3
ACA
3
Avoro Capital Advisors
New York
$167M
4
JPMorgan Chase & Co
4
JPMorgan Chase & Co
New York
$39.9M
5
State Street
5
State Street
Massachusetts
$77.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
Jane Street
51
Jane Street
New York
$7.46M +$4.82M +590,292 +182%
PCM
52
Peregrine Capital Management
Minnesota
$7.43M +$245K +29,991 +3%
Balyasny Asset Management
53
Balyasny Asset Management
Illinois
$7.37M +$439K +53,829 +6%
IECM
54
Intrinsic Edge Capital Management
Illinois
$7.13M +$1.63M +200,000 +30%
OCM
55
Osterweis Capital Management
California
$6.73M +$6.73M +824,740 New
AG
56
Algert Global
California
$6.69M +$3.22M +394,943 +93%
Connor, Clark & Lunn Investment Management (CC&L)
57
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$6.42M +$3.95M +483,698 +160%
PP
58
PDT Partners
New York
$6.05M +$3.17M +388,817 +110%
Barclays
59
Barclays
United Kingdom
$5.19M -$233K -28,562 -4%
DFCM
60
Dark Forest Capital Management
Puerto Rico
$5.11M +$4.8M +588,689 +1,543%
SIMG
61
Stephens Investment Management Group
Texas
$5M +$5M +612,470 New
KCM
62
Kodai Capital Management
Illinois
$4.94M +$4.94M +605,110 New
VOYA Investment Management
63
VOYA Investment Management
Georgia
$4.76M -$755K -92,508 -14%
PHP
64
Parkman Healthcare Partners
Connecticut
$4.64M -$1.76M -215,424 -27%
CSS
65
Cubist Systematic Strategies
Connecticut
$4.5M +$4.5M +552,025 New
Susquehanna International Group
66
Susquehanna International Group
Pennsylvania
$4.38M +$927K +113,544 +27%
SAM
67
Silvercrest Asset Management
New York
$4.36M -$12.6K -1,544 -0.3%
BNP Paribas Financial Markets
68
BNP Paribas Financial Markets
France
$4.1M +$150K +18,348 +4%
Assenagon Asset Management
69
Assenagon Asset Management
Luxembourg
$3.89M – – –
Voloridge Investment Management
70
Voloridge Investment Management
Florida
$3.87M -$3.31M -405,311 -46%
CM
71
CM Management
Florida
$3.67M – – –
Citigroup
72
Citigroup
New York
$3.64M -$946K -115,894 -21%
RhumbLine Advisers
73
RhumbLine Advisers
Massachusetts
$3.59M +$232K +28,383 +7%
Swiss National Bank
74
Swiss National Bank
Switzerland
$3.54M -$26.9K -3,300 -0.8%
Prudential Financial
75
Prudential Financial
New Jersey
$3.49M -$420K -51,500 -11%
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