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Amicus Therapeutics
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Overview Fund Activity

268 hedge funds and large institutions have $1.83B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 118 increasing their positions, 81 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
268
Holders Change
-13
Holders Change %
-4.63%
% of All Funds
3.59%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
118
Reduced
81
Closed
47
Calls
$2.41M
Puts
$1.56M
Net Calls
+$846K
Net Calls Change
+$2.68M

Top Buyers

1
VPC
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
Millennium Management
New York
$42.5M
4
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
$20.2M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$19.9M

Top Sellers

1
PA
Perceptive Advisors
New York
$42.5M
2
RG
Redmile Group
California
$6.81M
3
American Century Companies
American Century Companies
Missouri
$0
4
NHAS
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$12.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
Northern Trust
26
Northern Trust
Illinois
$17.7M -$1.63M -285,320 -8%
RHJA
27
Rice Hall James & Associates
California
$15.8M +$4.3M +750,210 +37%
Janus Henderson Group
28
Janus Henderson Group
United Kingdom
$15.8M -$3.25M -567,443 -17%
Charles Schwab
29
Charles Schwab
California
$14.6M +$326K +56,976 +2%
Blackstone Inc
30
Blackstone Inc
New York
$14.1M – – –
WP
31
Woodline Partners
California
$13.7M +$12M +2,085,616 +693%
O
32
OrbiMed
New York
$13.1M – – –
Voloridge Investment Management
33
Voloridge Investment Management
Florida
$12.7M +$10M +1,748,040 +368%
Hudson Bay Capital Management
34
Hudson Bay Capital Management
Connecticut
$12.7M -$1.48M -257,720 -10%
JPMorgan Chase & Co
35
JPMorgan Chase & Co
New York
$12.7M -$15.4M -2,684,013 -55%
CSS
36
Cubist Systematic Strategies
Connecticut
$12.6M +$9.46M +1,650,919 +299%
GIP
37
Granite Investment Partners
California
$12.4M +$406K +70,839 +3%
Renaissance Technologies
38
Renaissance Technologies
New York
$11.5M +$2.59M +451,600 +29%
MGP
39
M&G plc
United Kingdom
$11.3M +$11.3M +1,884,985 New
RSCM
40
Rock Springs Capital Management
Maryland
$11.2M +$292K +50,972 +3%
Connor, Clark & Lunn Investment Management (CC&L)
41
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$10.5M +$6.03M +1,053,015 +134%
UBS Group
42
UBS Group
Switzerland
$9.7M +$2.04M +356,421 +27%
Verition Fund Management
43
Verition Fund Management
Connecticut
$8.68M +$7.07M +1,233,880 +439%
PAM
44
Panagora Asset Management
Massachusetts
$8.27M -$4.65K -811 -0.1%
JF
45
Jump Financial
Illinois
$8.06M +$5.73M +1,000,395 +246%
AG
46
Algert Global
California
$7.76M +$3.06M +533,472 +65%
Invesco
47
Invesco
Georgia
$7.47M -$7.78M -1,357,430 -51%
Deutsche Bank
48
Deutsche Bank
Germany
$7.26M +$1.31M +228,313 +22%
SPS
49
Susquehanna Portfolio Strategies
Pennsylvania
$7.22M +$7.22M +1,259,259 New
UBS AM
50
UBS AM
Illinois
$7.2M +$1.05M +183,329 +17%
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