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Amicus Therapeutics
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Overview Fund Activity

281 hedge funds and large institutions have $2.53B invested in Amicus Therapeutics in 2025 Q1 according to their latest regulatory filings, with 41 funds opening new positions, 113 increasing their positions, 86 reducing their positions, and 41 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
281
Holders Change
-5
Holders Change %
-1.75%
% of All Funds
3.82%
Holding in Top 10
5
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+25%
% of All Funds
0.07%
New
41
Increased
113
Reduced
86
Closed
41
Calls
$3.21M
Puts
$5.05M
Net Calls
-$1.84M
Net Calls Change
-$1.73M

Top Buyers

1
Point72 Asset Management
1
Point72 Asset Management
Connecticut
$24.4M
2
Millennium Management
2
Millennium Management
New York
$27.4M
3
RG
3
Redmile Group
California
$77.8M
4
Bank of America
4
Bank of America
North Carolina
$45.7M
5
Two Sigma Investments
5
Two Sigma Investments
New York
$11.4M

Top Sellers

1
Fiera Capital (Canada)
1
Fiera Capital (Canada)
Quebec, Canada
$0
2
PA
2
Perceptive Advisors
New York
$175M
3
ACA
3
Avoro Capital Advisors
New York
$167M
4
JPMorgan Chase & Co
4
JPMorgan Chase & Co
New York
$39.9M
5
State Street
5
State Street
Massachusetts
$77.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
Charles Schwab
26
Charles Schwab
California
$20.3M -$781K -95,723 -4%
Hudson Bay Capital Management
27
Hudson Bay Capital Management
Connecticut
$20.2M +$5.43M +665,610 +37%
Blackstone Inc
28
Blackstone Inc
New York
$20.1M – – –
Morgan Stanley
29
Morgan Stanley
New York
$19.8M +$2.5M +306,466 +14%
D.E. Shaw & Co
30
D.E. Shaw & Co
New York
$18.7M +$5.96M +729,872 +47%
O
31
OrbiMed
New York
$18.6M – – –
GIP
32
Granite Investment Partners
California
$17.1M +$3.43M +420,829 +25%
RHJA
33
Rice Hall James & Associates
California
$16.4M +$5.21M +639,024 +47%
RSCM
34
Rock Springs Capital Management
Maryland
$15.6M -$5.63M -690,063 -27%
Pictet Asset Management
35
Pictet Asset Management
Switzerland
$13.7M +$932K +110,577 +7%
Aberdeen Group
36
Aberdeen Group
United Kingdom
$12.9M +$1.68M +205,834 +15%
Renaissance Technologies
37
Renaissance Technologies
New York
$12.7M -$4.46M -546,623 -26%
Squarepoint
38
Squarepoint
New York
$12.6M +$1M +122,770 +9%
PAM
39
Panagora Asset Management
Massachusetts
$11.8M +$86.8K +10,641 +0.7%
Two Sigma Investments
40
Two Sigma Investments
New York
$11.4M +$8.94M +1,095,326 +368%
PM
41
Prosight Management
Texas
$11.3M +$3.75M +459,383 +50%
UBS Group
42
UBS Group
Switzerland
$10.9M +$2.1M +256,840 +24%
T. Rowe Price Associates
43
T. Rowe Price Associates
Maryland
$10.5M -$698K -85,575 -6%
UBS AM
44
UBS AM
Illinois
$8.75M +$929K +113,803 +12%
Qube Research & Technologies (QRT)
45
Qube Research & Technologies (QRT)
United Kingdom
$8.74M +$2.18M +267,423 +33%
Deutsche Bank
46
Deutsche Bank
Germany
$8.48M +$1.77M +216,882 +26%
Two Sigma Advisers
47
Two Sigma Advisers
New York
$8.43M +$7.52M +921,300 +823%
Man Group
48
Man Group
United Kingdom
$8.31M +$7.86M +962,860 +1,737%
Bank of New York Mellon
49
Bank of New York Mellon
New York
$7.98M -$90.9K -11,139 -1%
Primecap Management
50
Primecap Management
California
$7.5M -$125K -15,300 -2%
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