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Dyne Therapeutics

197 hedge funds and large institutions have $1.23B invested in Dyne Therapeutics in 2025 Q2 according to their latest regulatory filings, with 23 funds opening new positions, 95 increasing their positions, 53 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more repeat investments, than reductions

Existing positions increased: 95 | Existing positions reduced: 53

20% more funds holding in top 10

Funds holding in top 10: 56 (+1)

5.29% more ownership

Funds ownership: 107.86%113.15% (+5.3%)

5% less capital invested

Capital invested by funds: $1.29B → $1.23B (-$62.7M)

4% less funds holding

Funds holding: 205197 (-8)

23% less first-time investments, than exits

New positions opened: 23 | Existing positions closed: 30

53% less call options, than puts

Call options by funds: $390K | Put options by funds: $823K

Holders
197
Holders Change
-8
Holders Change %
-3.9%
% of All Funds
2.59%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.08%
New
23
Increased
95
Reduced
53
Closed
30
Calls
$390K
Puts
$823K
Net Calls
-$433K
Net Calls Change
-$3.1M
Name Holding Trade Value Shares
Change
Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$92.5M
Janus Henderson Group
2
Janus Henderson Group
United Kingdom
$89.9M -$10.1M -915,454 -9%
AVLSA
3
Atlas Venture Life Science Advisors
Massachusetts
$86.9M
BlackRock
4
BlackRock
New York
$76.9M +$347K +31,490 +0.4%
Vanguard Group
5
Vanguard Group
Pennsylvania
$72.8M +$2.7M +244,813 +3%
FIS
6
FCPM III Services
Netherlands
$52M
Fidelity Investments
7
Fidelity Investments
Massachusetts
$50.4M +$1.08M +98,075 +2%
SL
8
Siren LLC
Connecticut
$46M +$23.3M +2,118,450 +78%
TCM
9
TCG Crossover Management
California
$35.9M +$12.3M +1,116,510 +42%
State Street
10
State Street
Massachusetts
$31.9M -$2.8M -253,973 -7%
B
11
Braidwell
Connecticut
$31.2M -$3.83M -347,995 -10%
Adage Capital Partners
12
Adage Capital Partners
Massachusetts
$30.4M +$35.1M +3,191,000 New
JP Morgan Chase
13
JP Morgan Chase
New York
$29.4M +$6.12M +555,466 +22%
AC
14
Armistice Capital
New York
$24.4M -$2.29M -208,000 -8%
T. Rowe Price Associates
15
T. Rowe Price Associates
Maryland
$22.7M +$6.2M +563,538 +31%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$21.5M +$3.28M +298,165 +15%
PA
17
Perceptive Advisors
New York
$21.4M -$727K -66,013 -3%
VA
18
VR Adviser
New York
$20.7M
LGM
19
Logos Global Management
California
$18.1M +$15.4M +1,400,000 +280%
T. Rowe Price Investment Management
20
T. Rowe Price Investment Management
Maryland
$17.1M +$6.89M +625,615 +54%
RI
21
RTW Investments
New York
$16.1M
FLSM
22
Frazier Life Sciences Management
California
$14.3M +$690K +62,643 +4%
SVCM
23
Saturn V Capital Management
Texas
$13.9M +$16M +1,455,429 New
MB
24
MPM BioImpact
Massachusetts
$13.8M +$15.9M +1,446,361 New
Franklin Resources
25
Franklin Resources
California
$13.2M -$272K -24,695 -2%

DYN Hedge Fund Activity: Q2 2025 in Review

197 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Dyne Therapeutics (DYN) for Q2 2025, worth a combined $1.23B — down 4.9% from $1.29B a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of DYN and 23 opened new positions — a net loss of 7 holders — while 53 trimmed existing stakes and 95 added.

The largest buyer was Adage Capital Partners, opening a new position worth an estimated $35.1M. The largest seller was Citadel Advisors, cutting an estimated $22.7M.

  • 197 institutional investors held Dyne Therapeutics (DYN) as of Q2 2025, down from 205 in Q1 2025.
  • Funds reported $1.23B of Dyne Therapeutics stock for Q2 2025, down 4.9% quarter-over-quarter.
  • 23 funds opened new Dyne Therapeutics positions in Q2 2025 and 30 closed out, a net change of -7 holders.
  • The largest Dyne Therapeutics buyer in Q2 2025 was Adage Capital Partners, an estimated $35.1M added.
  • The largest Dyne Therapeutics seller in Q2 2025 was Citadel Advisors, an estimated $22.7M sold.

Based on aggregated 13F filings for Q2 2025.